Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes

TY - JOUR

T1 - Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes

AU - Silva, E.F. Da Cruz e

AU - Hughes, V.

AU - McDonald, P.

AU - Stark, M.J.R.

AU - Cohen, P.T.W.

PY - 1991/6/13

Y1 - 1991/6/13

N2 - cDNAs encoding three protein phosphatases, termed PP2B(w) (Da Cruz e Silva, E.F. and Cohen, P.T.W. (1989) Biochim. Biophys. Acta 1009, 293-296), PPZ1 and PPZ2 that have been isolated from a Clontech 'rabbit brain' library are shown to be Saccharomyces cerevisiae clones. PPZ1 and PPZ2 are two novel yeast phosphatases showing 93% amino acid sequence identity to one another. PPZ1 shows approx. 60% sequence identity to S. cerevisiae or mammalian PP1 and approx. 40% identity to S. cerevisiae or mammalian PP2A. These and other observations suggest that the two isoforms of PPZ have functions distinct from those of PP1.

AB - cDNAs encoding three protein phosphatases, termed PP2B(w) (Da Cruz e Silva, E.F. and Cohen, P.T.W. (1989) Biochim. Biophys. Acta 1009, 293-296), PPZ1 and PPZ2 that have been isolated from a Clontech 'rabbit brain' library are shown to be Saccharomyces cerevisiae clones. PPZ1 and PPZ2 are two novel yeast phosphatases showing 93% amino acid sequence identity to one another. PPZ1 shows approx. 60% sequence identity to S. cerevisiae or mammalian PP1 and approx. 40% identity to S. cerevisiae or mammalian PP2A. These and other observations suggest that the two isoforms of PPZ have functions distinct from those of PP1.

U2 - 10.1016/0167-4781(91)90023-F

DO - 10.1016/0167-4781(91)90023-F

M3 - Comment/debate

SN - 0304-4165

VL - 1089

SP - 269

EP - 272

JO - BBA - General Subjects

JF - BBA - General Subjects

IS - 2

ER -