Protein phosphatases: Properties and role in cellular regulation

Thomas S. Ingebritsen, Philip Cohen

    Research output: Contribution to journalArticlepeer-review

    468 Citations (Scopus)

    Abstract

    Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.

    Original languageEnglish
    Pages (from-to)331-338
    Number of pages8
    JournalScience
    Volume221
    Issue number4608
    DOIs
    Publication statusPublished - 22 Jul 1983

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