TY - JOUR
T1 - Protein phosphatases
T2 - Properties and role in cellular regulation
AU - Ingebritsen, Thomas S.
AU - Cohen, Philip
PY - 1983/7/22
Y1 - 1983/7/22
N2 - Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.
AB - Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.
UR - http://www.scopus.com/inward/record.url?scp=0020565637&partnerID=8YFLogxK
U2 - 10.1126/science.6306765
DO - 10.1126/science.6306765
M3 - Article
C2 - 6306765
AN - SCOPUS:0020565637
SN - 0036-8075
VL - 221
SP - 331
EP - 338
JO - Science
JF - Science
IS - 4608
ER -