Protein quality control in the endoplasmic reticulum

Ben P. Phillips, Natalia Gomez-Navarro, Elizabeth A. Miller (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)
1 Downloads (Pure)

Abstract

Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the discovery of new mechanisms that contribute to this protective network. Biochemical and structural advances in endoplasmic reticulum targeting fidelity, and in the redistribution of mistargeted substrates are discussed. We further review new discoveries in quality control at the inner nuclear membrane in the context of orphaned subunits. We consider developments in our understanding of cargo selection for endoplasmic reticulum export. Conflicting data on quality control by cargo receptor proteins are discussed and we look to important future questions for the field.
Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume65
Early online date11 May 2020
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Protein quality control
  • Endoplasmic reticulum

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