TY - JOUR
T1 - Protein quality control in the endoplasmic reticulum
AU - Phillips, Ben P.
AU - Gomez-Navarro, Natalia
AU - Miller, Elizabeth A.
N1 - © 2020 MRC Laboratory of Molecular Biology. Published by
Elsevier Ltd.
PY - 2020/8
Y1 - 2020/8
N2 - Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the discovery of new mechanisms that contribute to this protective network. Biochemical and structural advances in endoplasmic reticulum targeting fidelity, and in the redistribution of mistargeted substrates are discussed. We further review new discoveries in quality control at the inner nuclear membrane in the context of orphaned subunits. We consider developments in our understanding of cargo selection for endoplasmic reticulum export. Conflicting data on quality control by cargo receptor proteins are discussed and we look to important future questions for the field.
AB - Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats. We focus on the discovery of new mechanisms that contribute to this protective network. Biochemical and structural advances in endoplasmic reticulum targeting fidelity, and in the redistribution of mistargeted substrates are discussed. We further review new discoveries in quality control at the inner nuclear membrane in the context of orphaned subunits. We consider developments in our understanding of cargo selection for endoplasmic reticulum export. Conflicting data on quality control by cargo receptor proteins are discussed and we look to important future questions for the field.
KW - Protein quality control
KW - Endoplasmic reticulum
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85084370283&origin=inward
U2 - 10.1016/j.ceb.2020.04.002
DO - 10.1016/j.ceb.2020.04.002
M3 - Review article
C2 - 32408120
SN - 0955-0674
VL - 65
SP - 96
EP - 102
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -