Protein sequence alignment techniques

Geoffrey J. Barton (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The basic algorithms for alignment of two or more protein sequences are explained. Alternative methods for scoring substitutions and gaps (insertions and deletions) are described, as are global and local alignment methods. Multiple alignment techniques are explained, including methods for profile comparison. A summary is given of programs for the alignment and analysis of protein sequences, either from sequence alone, or from three-dimensional structure.

Original languageEnglish
Pages (from-to)1139-1146
Number of pages8
JournalActa Crystallographica Section D: Biological Crystallography
Issue number6, no. 1
Publication statusPublished - 1 Nov 1998


  • Algorithms
  • Protein conformation
  • Sequence alignment


Dive into the research topics of 'Protein sequence alignment techniques'. Together they form a unique fingerprint.

Cite this