The basic algorithms for alignment of two or more protein sequences are explained. Alternative methods for scoring substitutions and gaps (insertions and deletions) are described, as are global and local alignment methods. Multiple alignment techniques are explained, including methods for profile comparison. A summary is given of programs for the alignment and analysis of protein sequences, either from sequence alone, or from three-dimensional structure.
|Number of pages||8|
|Journal||Acta Crystallographica Section D: Biological Crystallography|
|Issue number||6, no. 1|
|Publication status||Published - 1 Nov 1998|
- Protein conformation
- Sequence alignment