Protein synthesis, degradation, and energy metabolism in T cell immunity

Julia M. Marchingo, Doreen A. Cantrell (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)
194 Downloads (Pure)


T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.
Original languageEnglish
Pages (from-to)303-315
Number of pages13
JournalCellular & Molecular Immunology
Early online date4 Jan 2022
Publication statusPublished - Mar 2022


  • Immunometabolism
  • Protein Translation
  • Protein degradation
  • Proteomics
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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