Protein synthesis, degradation, and energy metabolism in T cell immunity

Julia M. Marchingo; Doreen A. Cantrell

doi:10.1038/s41423-021-00792-8

Protein synthesis, degradation, and energy metabolism in T cell immunity

Julia M. Marchingo, Doreen A. Cantrell (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

273 Downloads (Pure)

Abstract

T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

Original language	English
Pages (from-to)	303-315
Number of pages	13
Journal	Cellular & Molecular Immunology
Volume	19
Early online date	4 Jan 2022
DOIs	https://doi.org/10.1038/s41423-021-00792-8
Publication status	Published - Mar 2022

Keywords

Immunometabolism
Protein Translation
Protein degradation
Proteomics
T lymphocyte

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41423-021-00792-8Licence: CC BY

Final published versionFinal published version, 2.19 MBLicence: CC BY

Cite this

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title = "Protein synthesis, degradation, and energy metabolism in T cell immunity",

abstract = "T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.",

keywords = "Immunometabolism, Protein Translation, Protein degradation, Proteomics, T lymphocyte",

author = "Marchingo, {Julia M.} and Cantrell, {Doreen A.}",

note = "Funding Information: The authors thank Linda V. Sinclair for critical reading and insightful feedback on the manuscript. We also thank members of the Cantrell group for valuable discussions on the topics covered. DAC is supported by a Wellcome Trust Principal Research Fellowship (205023/Z/16/Z), and JMM is supported by an Australian NHMRC CJ Martin Early Career Fellowship. Figures were created using BioRender.com. Figure 1a was adapted from the template “Protein Translation” by BioRender.com (2021) retrieved from https://app.biorender.com/biorender-templates. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Marchingo, Julia M.

AU - Cantrell, Doreen A.

N1 - Funding Information: The authors thank Linda V. Sinclair for critical reading and insightful feedback on the manuscript. We also thank members of the Cantrell group for valuable discussions on the topics covered. DAC is supported by a Wellcome Trust Principal Research Fellowship (205023/Z/16/Z), and JMM is supported by an Australian NHMRC CJ Martin Early Career Fellowship. Figures were created using BioRender.com. Figure 1a was adapted from the template “Protein Translation” by BioRender.com (2021) retrieved from https://app.biorender.com/biorender-templates. Publisher Copyright: © 2021, The Author(s).

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AB - T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

KW - Immunometabolism

KW - Protein Translation

KW - Protein degradation

KW - Proteomics

KW - T lymphocyte

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DO - 10.1038/s41423-021-00792-8

M3 - Review article

C2 - 34983947

SN - 1672-7681

VL - 19

SP - 303

EP - 315

JO - Cellular & Molecular Immunology

JF - Cellular & Molecular Immunology

ER -

Protein synthesis, degradation, and energy metabolism in T cell immunity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Serine Kinase Pathways that Determine T Lymphocyte Activation and Cell Fate Choices (Principal Research Fellowship renewal)

Unravelling how Protein Signalling Networks Integrate to Control T Cell Fate (Fellowship)

Cite this

Protein synthesis, degradation, and energy metabolism in T cell immunity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

Serine Kinase Pathways that Determine T Lymphocyte Activation and Cell Fate Choices (Principal Research Fellowship renewal)

Unravelling how Protein Signalling Networks Integrate to Control T Cell Fate (Fellowship)

Cite this