Protein synthesis, degradation, and energy metabolism in T cell immunity

TY - JOUR

T1 - Protein synthesis, degradation, and energy metabolism in T cell immunity

AU - Marchingo, Julia M.

AU - Cantrell, Doreen A.

N1 - Funding Information: The authors thank Linda V. Sinclair for critical reading and insightful feedback on the manuscript. We also thank members of the Cantrell group for valuable discussions on the topics covered. DAC is supported by a Wellcome Trust Principal Research Fellowship (205023/Z/16/Z), and JMM is supported by an Australian NHMRC CJ Martin Early Career Fellowship. Figures were created using BioRender.com. Figure 1a was adapted from the template “Protein Translation” by BioRender.com (2021) retrieved from https://app.biorender.com/biorender-templates. Publisher Copyright: © 2021, The Author(s).

PY - 2022/3

Y1 - 2022/3

N2 - T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

AB - T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

KW - Immunometabolism

KW - Protein Translation

KW - Protein degradation

KW - Proteomics

KW - T lymphocyte

UR - https://www.scopus.com/pages/publications/85122266160

U2 - 10.1038/s41423-021-00792-8

DO - 10.1038/s41423-021-00792-8

M3 - Review article

C2 - 34983947

SN - 1672-7681

VL - 19

SP - 303

EP - 315

JO - Cellular & Molecular Immunology

JF - Cellular & Molecular Immunology

ER -