Protein targeting by the bacterial twin-arginine translocation (Tat) pathway

Ben C. Berks, Tracy Palmer, Frank Sargent

    Research output: Contribution to journalArticlepeer-review

    181 Citations (Scopus)

    Abstract

    The Tat (twin-arginine translocation) protein export system is found in the cytoplasmic membrane of most prokaryotes; and is dedicated to the transport of folded proteins. The Tat system is now known to be essential for many bacterial processes including energy metabolism, cell wall biosynthesis, the nitrogen-fixing symbiosis and bacterial pathogenesis. Recent studies demonstrate that substrate-specific accessory proteins prevent improperly assembled substrates from interacting with the Tat transporter. During the transport cycle itself substrate proteins bind to a receptor complex in the membrane which then recruits a protein-translocating channel to carry out the transport reaction.

    Original languageEnglish
    Pages (from-to)174-181
    Number of pages8
    JournalCurrent Opinion in Microbiology
    Volume8
    Issue number2
    DOIs
    Publication statusPublished - 2005

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