PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

Alessio Ciulli; Christian Dank; Emelyne Diers; William Farnaby; Michael Roy; Steffen Steurer; Nicole Trainor

PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

Alessio Ciulli (Inventor)
, Christian Dank (Inventor)
, Emelyne Diers (Inventor)
, William Farnaby (Inventor)
, Michael Roy (Inventor)
, Steffen Steurer (Inventor)
, Nicole Trainor (Inventor)

Biological Chemistry and Drug Discovery

Research output: Patent

Abstract

The present invention encompasses compounds of formula (I) wherein the groups R1, A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Original language	English
Patent number	WO/2020/078933
Priority date	16/10/18
Filing date	14/10/19
Publication status	Published - 23 Apr 2020

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title = "PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4",

abstract = "The present invention encompasses compounds of formula (I) wherein the groups R1, A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.",

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T1 - PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

AU - Ciulli, Alessio

AU - Dank, Christian

AU - Diers, Emelyne

AU - Farnaby, William

AU - Roy, Michael

AU - Steurer, Steffen

AU - Trainor, Nicole

PY - 2020/4/23

Y1 - 2020/4/23

N2 - The present invention encompasses compounds of formula (I) wherein the groups R1, A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

AB - The present invention encompasses compounds of formula (I) wherein the groups R1, A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

M3 - Patent

M1 - WO/2020/078933

Y2 - 2019/10/14

ER -

PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

Abstract

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