Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device

Lauren Sullivan; Steven J. Wall; Mark Carrington; Michael A. J. Ferguson

doi:10.1371/journal.pntd.0002087

Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device

Lauren Sullivan, Steven J. Wall, Mark Carrington, Michael A. J. Ferguson

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypanosome antigens.

Original language	English
Article number	e2087
Number of pages	14
Journal	PLoS Neglected Tropical Diseases
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.pntd.0002087
Publication status	Published - 28 Feb 2013

Keywords

Animals
Antibodies, Protozoan
Antigens, Protozoan
Humans
Immunochromatography
Immunoglobulin G
Mice
Sensitivity and Specificity
Trypanosoma brucei gambiense
Trypanosomiasis, African

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10.1371/journal.pntd.0002087

http://www.plosntds.org/

A Translational Engine for Biomedical Discoveries (Strategic Grant)
Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)
1/01/13 → 30/09/15
Project: Research
Aref#d: 20731. The Biosynthesis of Glycoproteins in Trypanosoma Brucei: Basic and Translational Research
Ferguson, M. (Investigator) & Gilbert, I. (Investigator)
1/10/08 → 31/05/14
Project: Research
Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)
Fairlamb, A. (Investigator), Ferguson, M. (Investigator) & Frearson, J. (Investigator)
1/01/08 → 31/12/12
Project: Research

Cite this

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title = "Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device",

abstract = "The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypanosome antigens.",

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AU - Carrington, Mark

AU - Ferguson, Michael A. J.

PY - 2013/2/28

Y1 - 2013/2/28

N2 - The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypanosome antigens.

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KW - Animals

KW - Antibodies, Protozoan

KW - Antigens, Protozoan

KW - Humans

KW - Immunochromatography

KW - Immunoglobulin G

KW - Mice

KW - Sensitivity and Specificity

KW - Trypanosoma brucei gambiense

KW - Trypanosomiasis, African

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DO - 10.1371/journal.pntd.0002087

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ER -

Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device

Abstract

Keywords

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Projects

A Translational Engine for Biomedical Discoveries (Strategic Grant)

Aref#d: 20731. The Biosynthesis of Glycoproteins in Trypanosoma Brucei: Basic and Translational Research

Aref#d: 19815. Wellcome Trust Centre for Drug Discovery (Strategic Award)

Cite this