Proteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device

Lauren Sullivan, Steven J. Wall, Mark Carrington, Michael A. J. Ferguson

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    The diagnosis of Human African Trypanosomiasis relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). While this test is successful, it is acknowledged that there may be room for improvement. Our aim was to develop a prototype lateral flow test based on the detection of antibodies to trypanosome antigens.
    Original languageEnglish
    Article numbere2087
    Number of pages14
    JournalPLoS Neglected Tropical Diseases
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - 28 Feb 2013

    Keywords

    • Animals
    • Antibodies, Protozoan
    • Antigens, Protozoan
    • Humans
    • Immunochromatography
    • Immunoglobulin G
    • Mice
    • Sensitivity and Specificity
    • Trypanosoma brucei gambiense
    • Trypanosomiasis, African

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