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Protoplast Transformation of Phytophthora spp.

  • Lydia R.J. Welsh
  • , Stephen C. Whisson (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

At the core of assays to understand the role(s) of specific genes is the ability to stably transfer genes into Phytophthora through transformation. A key method for achieving this has been based on polyethylene glycol (PEG)/CaCl2 transformation of protoplasts, but efficiency has often been low. Improving transformation efficiency is necessary for many applications, such as gene knockouts. Here we describe improvements through successive rounds of “mock” transformation, leading to improved efficiency in Phytophthora infestans and other species.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsMonica L. Gerth, Rosie E. Bradshaw
PublisherHumana Press
Pages35-47
Number of pages13
ISBN (Electronic)9781071643303
ISBN (Print)9781071643297
DOIs
Publication statusPublished - 28 Dec 2024

Publication series

NameMethods in Molecular Biology
Volume2892
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Antibiotic selection
  • Oomycete
  • Phytophthora
  • Protoplasts
  • Transformation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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