Proximal effects of Toll-like receptor activation in dendritic cells

Colin Watts, Rossana Zaru, Alan R Prescott, Robert P Wallin, Michele A West

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    Toll-like receptor (TLR) signals induce dendritic cell (DC) differentiation and influence the immunological outcome of their interactions with T cells. Recent in vitro studies demonstrate that TLR signals also trigger striking reorganisation of the DC vacuolar compartments, the cytoskeleton and the machinery of protein translation and turnover. Moreover, TLR ligation within endosomes and phagosomes appears to establish organelle autonomous signals. These changes, which mostly occur within minutes to a few hours after TLR engagement, are adaptations relevant to the antigen capture, processing and migratory phases of the DC life history.

    Original languageEnglish
    Pages (from-to)73-8
    Number of pages6
    JournalCurrent Opinion in Immunology
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - Feb 2007

    Keywords

    • Animals
    • Dendritic Cells
    • Humans
    • Signal Transduction
    • Toll-Like Receptors

    Fingerprint

    Dive into the research topics of 'Proximal effects of Toll-like receptor activation in dendritic cells'. Together they form a unique fingerprint.

    Cite this