Proximal effects of Toll-like receptor activation in dendritic cells

Colin Watts, Rossana Zaru, Alan R Prescott, Robert P Wallin, Michele A West

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)


    Toll-like receptor (TLR) signals induce dendritic cell (DC) differentiation and influence the immunological outcome of their interactions with T cells. Recent in vitro studies demonstrate that TLR signals also trigger striking reorganisation of the DC vacuolar compartments, the cytoskeleton and the machinery of protein translation and turnover. Moreover, TLR ligation within endosomes and phagosomes appears to establish organelle autonomous signals. These changes, which mostly occur within minutes to a few hours after TLR engagement, are adaptations relevant to the antigen capture, processing and migratory phases of the DC life history.

    Original languageEnglish
    Pages (from-to)73-8
    Number of pages6
    JournalCurrent Opinion in Immunology
    Issue number1
    Publication statusPublished - Feb 2007


    • Animals
    • Dendritic Cells
    • Humans
    • Signal Transduction
    • Toll-Like Receptors


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