Proximity-Based Modalities for Biology and Medicine

Xingui Liu, Alessio Ciulli (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
59 Downloads (Pure)

Abstract

Molecular proximity orchestrates biological function, and blocking existing proximities is an established therapeutic strategy. By contrast, strengthening or creating neoproximity with chemistry enables modulation of biological processes with high selectivity and has the potential to substantially expand the target space. A plethora of proximity-based modalities to target proteins via diverse approaches have recently emerged, opening opportunities for biopharmaceutical innovation. This Outlook outlines the diverse mechanisms and molecules based on induced proximity, including protein degraders, blockers, and stabilizers, inducers of protein post-translational modifications, and agents for cell therapy, and discusses opportunities and challenges that the field must address to mature and unlock translation in biology and medicine.
Original languageEnglish
Pages (from-to)1269-1284
Number of pages16
JournalACS Central Science
Volume9
Issue number7
Early online date14 Jul 2023
DOIs
Publication statusPublished - 26 Jul 2023

Keywords

  • Cells
  • Degradation
  • Ligands
  • Molecules
  • Peptides and proteins

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Chemistry

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