Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomized controlled trial

J. Hancox, K. Ayling, L. Bedford, K. Vedhara, J. F. R. Roberston, B. Young, R. das Nair, F. M. Sullivan, S. Schembri, F. S. Mair, R. Littleford, D. Kendrick (Lead / Corresponding author)

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3 Citations (Scopus)
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Abstract

Background: The Early CDT®-Lung antibody blood test plus serial computed tomography scans for test-positives (TPGs) reduces late-stage lung cancer presentation. This study assessed the psychological outcomes of this approach.

Methods: Randomized controlled trial (n = 12 208) comparing psychological outcomes 1-12 months post-recruitment in a subsample (n = 1032) of TPG, test-negative (TNG) and control groups (CG).

Results: Compared to TNG, TPG had lower positive affect (difference between means (DBM), 3 months (3m: -1.49 (-2.65, - 0.33)), greater impact of worries (DBM 1m: 0.26 (0.05, 0.47); 3m: 0.28 (0.07, 0.50)), screening distress (DBM 1m: 3.59 (2.28, 4.90); 3m: 2.29 (0.97, 3.61); 6m: 1.94 (0.61, 3.27)), worry about tests (odds ratio (OR) 1m: 5.79 (2.66, 12.63) and more frequent lung cancer worry (OR 1m: 2.52 (1.31, 4.83); 3m: 2.43 (1.26, 4.68); 6m: 2.87 (1.48, 5.60)). Compared to CG, TPG had greater worry about tests (OR 1m: 3.40 (1.69, 6.84)). TNG had lower negative affect (log-transformed DBM 3m: -0.08 (-0.13, -0.02)), higher positive affect (DBM 1m: 1.52 (0.43, 2.61); 3m: 1.43 (0.33, 2.53); 6m: 1.27 (0.17, 2.37)), less impact of worries (DBM 3m: -0.27 (-0.48, -0.07)) and less-frequent lung cancer worry (OR 3m: 0.49 (0.26, 0.92)).

Conclusions: Negative psychological effects in TPG and positive effects in TNG were short-lived and most differences were small.

Original languageEnglish
Pages (from-to)E275-E284
Number of pages10
JournalJournal of Public Health
Volume45
Issue number2
Early online date14 Mar 2022
DOIs
Publication statusPublished - Jun 2023

Keywords

  • behavioural medicine
  • early detection of cancer
  • lung neoplasms
  • psychology
  • screening

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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