Psychometrics of health-related quality of life questionnaires in bronchiectasis: A systematic review and meta-analysis

Rebecca H. McLeese, Arietta Spinou, Zina Alfahl, Michail Tsagris, J. Stuart Elborn, James D. Chalmers, Anthony De Soyza, Michael R. Loebinger, Surinder S. Birring, Konstantinos C. Fragkos, Robert Wilson, Katherine O'Neill, Judy M. Bradley

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
27 Downloads (Pure)

Abstract

Introduction: Understanding the psychometric properties of health-related quality of life (HRQoL) questionnaires can help inform selection in clinical trials. Our objective was to assess the psychometric properties of HRQoL questionnaires in bronchiectasis using a systematic review and meta-analysis of the literature.

Methods: A literature search was conducted. HRQoL questionnaires were assessed for psychometric properties (reliability, validity, minimal clinically important difference (MCID) and floor/ceiling effects). Meta-analyses assessed the associations of HRQoL with clinical measures and responsiveness of HRQoL in clinical trials.

Results: 166 studies and 12 HRQoL questionnaires were included. The Bronchiectasis Health Questionnaire (BHQ), Leicester Cough Questionnaire (LCQ), Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) and Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) had good internal consistency in all domains reported (Cronbach’s α≥0.7) across all studies, and the Quality of Life-Bronchiectasis (QOL-B), St George’s Respiratory Questionnaire (SGRQ), Chronic Respiratory Disease Questionnaire (CRDQ) and Seattle Obstructive Lung Disease Questionnaire (SOLQ) had good internal consistency in all domains in the majority of (but not all) studies. BHQ, SGRQ, LCQ and CAT had good test–retest reliability in all domains reported (intraclass correlation coefficient ≥0.7) across all studies, and QOL-B, CRDQ and SOLQ had good test–retest reliability in all domains in the majority of (but not all) studies. HRQoL questionnaires were able to discriminate between demographics, important markers of clinical status, disease severity, exacerbations and bacteriology. For HRQoL responsiveness, there was a difference between the treatment and placebo effect.

Conclusions: SGRQ was the most widely used HRQoL questionnaire in bronchiectasis studies and it had good psychometric properties; however, good psychometric data are emerging on the bronchiectasis-specific HRQoL questionnaires QOL-B and BHQ. Future studies should focus on the medium- to long-term test–retest reliability, responsiveness and MCID in these HRQoL questionnaires which show potential in bronchiectasis.

Original languageEnglish
Article number2100025
Number of pages16
JournalEuropean Respiratory Journal
Volume58
Issue number5
Early online date22 Apr 2021
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • bronchiectasis
  • health-related quality of life
  • questionnaires
  • psychometrics
  • systematic review
  • meta-analysis

Fingerprint

Dive into the research topics of 'Psychometrics of health-related quality of life questionnaires in bronchiectasis: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this