PTEN regulates cilia through Dishevelled

Iryna Shnitsar, Mikhail Bashkurov, Glenn R. Masson, Abiodun A. Ogunjimi, Sherly Mosessian, Eduardo Aguiar Cabeza, Calley L. Hirsch, Daniel Trcka, Gerald Gish, Jing Jiao, Hong Wu, Rudolf Winklbauer, Roger L. Williams, Laurence Pelletier, Jeffrey L. Wrana (Lead / Corresponding author), Miriam Barrios-Rodiles (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial surfaces, while primary (sensory) cilia play roles in cellular signalling. The molecular events underlying cilia dynamics, and particularly their disassembly, are not well understood. Phosphatase and tensin homologue (PTEN) is an extensively studied tumour suppressor, thought to primarily act by antagonizing PI3-kinase signalling. Here we demonstrate that PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (DVL), another ciliogenesis regulator. DVL is a central component of WNT signalling that plays a role during convergent extension movements, which we show here are also regulated by PTEN. Our studies identify a novel protein substrate for PTEN that couples PTEN to regulation of cilia dynamics and WNT signalling, thus advancing our understanding of potential underlying molecular etiologies of PTEN-related pathologies.

Original languageEnglish
Article number8388
Number of pages14
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 24 Sept 2015

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy

Fingerprint

Dive into the research topics of 'PTEN regulates cilia through Dishevelled'. Together they form a unique fingerprint.

Cite this