Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research

Adam T. Hill; Charles S. Haworth; Stefano Aliberti; Alan Barker; Francesco Blasi; Wim Boersma; James D. Chalmers; Anthony De Soyza; Katerina Dimakou; J. Stuart Elborn; Charles Feldman; Patrick Flume; Pieter C. Goeminne; Michael R. Loebinger; Rosario Menendez; Lucy Morgan; Marlene Murris-Espin; Eva Polverino; Alexandra Quittner; Felix C. Ringshausen; Gregory Tino; Antoni Torres; Montserrat Vendrell; Tobias Welte; Rob Wilson; Conroy Wong; Anne O'Donnell; Timothy Aksamit; for the EMBARC/BRR definitions working group

doi:10.1183/13993003.00051-2017

Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research

Adam T. Hill (Lead / Corresponding author), Charles S. Haworth, Stefano Aliberti, Alan Barker, Francesco Blasi, Wim Boersma, James D. Chalmers, Anthony De Soyza, Katerina Dimakou, J. Stuart Elborn, Charles Feldman, Patrick Flume, Pieter C. Goeminne, Michael R. Loebinger, Rosario Menendez, Lucy Morgan, Marlene Murris-Espin, Eva Polverino, Alexandra Quittner, Felix C. RingshausenGregory Tino, Antoni Torres, Montserrat Vendrell, Tobias Welte, Rob Wilson, Conroy Wong, Anne O'Donnell, Timothy Aksamit, for the EMBARC/BRR definitions working group

Research output: Contribution to journal › Article › peer-review

279 Citations (Scopus)

Abstract

There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.

Original language	English
Article number	1700051
Number of pages	8
Journal	European Respiratory Journal
Volume	49
Issue number	6
DOIs	https://doi.org/10.1183/13993003.00051-2017
Publication status	Published - 1 Jun 2017

Keywords

Journal article

Access to Document

10.1183/13993003.00051-2017Licence: No Licence / Unknown

Chalmers, James
- Respiratory Medicine and Gastroenterology - Clinical Professor (Teaching and Research) of Respiratory Research
Person: Academic

Cite this

Hill, A. T., Haworth, C. S., Aliberti, S., Barker, A., Blasi, F., Boersma, W., Chalmers, J. D., De Soyza, A., Dimakou, K., Elborn, J. S., Feldman, C., Flume, P., Goeminne, P. C., Loebinger, M. R., Menendez, R., Morgan, L., Murris-Espin, M., Polverino, E., Quittner, A., ... for the EMBARC/BRR definitions working group (2017). Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research. European Respiratory Journal, 49(6), Article 1700051. https://doi.org/10.1183/13993003.00051-2017

@article{f90e5b45b2064111a8d0a8454a960ad5,

title = "Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research",

abstract = "There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.",

keywords = "Journal article",

author = "Hill, {Adam T.} and Haworth, {Charles S.} and Stefano Aliberti and Alan Barker and Francesco Blasi and Wim Boersma and Chalmers, {James D.} and {De Soyza}, Anthony and Katerina Dimakou and Elborn, {J. Stuart} and Charles Feldman and Patrick Flume and Goeminne, {Pieter C.} and Loebinger, {Michael R.} and Rosario Menendez and Lucy Morgan and Marlene Murris-Espin and Eva Polverino and Alexandra Quittner and Ringshausen, {Felix C.} and Gregory Tino and Antoni Torres and Montserrat Vendrell and Tobias Welte and Rob Wilson and Conroy Wong and Anne O'Donnell and Timothy Aksamit and {for the EMBARC/BRR definitions working group}",

note = "This project was funded by EMBARC, a European Respiratory Society Clinical Research Collaboration. Funding information for this article has been deposited with the Crossref Funder Registry.",

year = "2017",

month = jun,

day = "1",

doi = "10.1183/13993003.00051-2017",

language = "English",

volume = "49",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "6",

}

Hill, AT, Haworth, CS, Aliberti, S, Barker, A, Blasi, F, Boersma, W, Chalmers, JD, De Soyza, A, Dimakou, K, Elborn, JS, Feldman, C, Flume, P, Goeminne, PC, Loebinger, MR, Menendez, R, Morgan, L, Murris-Espin, M, Polverino, E, Quittner, A, Ringshausen, FC, Tino, G, Torres, A, Vendrell, M, Welte, T, Wilson, R, Wong, C, O'Donnell, A, Aksamit, T & for the EMBARC/BRR definitions working group 2017, 'Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research', European Respiratory Journal, vol. 49, no. 6, 1700051. https://doi.org/10.1183/13993003.00051-2017

TY - JOUR

T1 - Pulmonary exacerbation in adults with bronchiectasis

T2 - a consensus definition for clinical research

AU - Hill, Adam T.

AU - Haworth, Charles S.

AU - Aliberti, Stefano

AU - Barker, Alan

AU - Blasi, Francesco

AU - Boersma, Wim

AU - Chalmers, James D.

AU - De Soyza, Anthony

AU - Dimakou, Katerina

AU - Elborn, J. Stuart

AU - Feldman, Charles

AU - Flume, Patrick

AU - Goeminne, Pieter C.

AU - Loebinger, Michael R.

AU - Menendez, Rosario

AU - Morgan, Lucy

AU - Murris-Espin, Marlene

AU - Polverino, Eva

AU - Quittner, Alexandra

AU - Ringshausen, Felix C.

AU - Tino, Gregory

AU - Torres, Antoni

AU - Vendrell, Montserrat

AU - Welte, Tobias

AU - Wilson, Rob

AU - Wong, Conroy

AU - O'Donnell, Anne

AU - Aksamit, Timothy

AU - for the EMBARC/BRR definitions working group

N1 - This project was funded by EMBARC, a European Respiratory Society Clinical Research Collaboration. Funding information for this article has been deposited with the Crossref Funder Registry.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.

AB - There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.

KW - Journal article

U2 - 10.1183/13993003.00051-2017

DO - 10.1183/13993003.00051-2017

M3 - Article

C2 - 28596426

SN - 0903-1936

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 6

M1 - 1700051

ER -

Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research

Abstract

Keywords

Access to Document

Fingerprint

Profiles

Chalmers, James

Cite this