PXR and CAR: Nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

Lesley Stanley, Brian Horsburgh, Jillian Ross, Nico Scheer, C. Roland Wolf

Research output: Contribution to journalReview articlepeer-review

121 Citations (Scopus)

Abstract

Xenobiotic metabolism and detoxification is regulated by receptors (e.g., PXR, CAR) whose characterization has contributed significantly to our understanding of drug responses in humans. Technologies facilitating the screening of compounds for receptor interactions provide valuable tools applicable in drug development. Most use in vitro systems or mice humanized for receptors in vivo. In vitro assays are limited by the reporter systems and cell lines chosen and are uninformative about effects in vivo. Humanized mouse models provide novel, exciting ways of understanding the functions of these genes. This article evaluates these technologies and current knowledge on PXR/CAR-mediated regulation of gene expression.

Original languageEnglish
Pages (from-to)515-597
Number of pages83
JournalDrug Metabolism Reviews
Volume38
Issue number3
DOIs
Publication statusPublished - 1 Jun 2006

Keywords

  • Constitutive androstane receptor
  • CYP2B
  • CYP3A
  • Cytochrome P450
  • Humanised mice
  • Null mice
  • Pregnane-X-receptor
  • Transcription factors

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