Abstract
We here describe the use of three-component reactions to synthesize tricyclic pyridine ring-fused 2-pyridones. The developed protocols have a wide substrate scope and allow for the installation of diverse chemical functionalities on the tricyclic central fragment. Several of these pyridine-fused rigid polyheterocycles are shown to bind to Aβ and α-synuclein fibrils, which are associated with neurodegenerative diseases.
Original language | English |
---|---|
Pages (from-to) | 3887-3903 |
Number of pages | 17 |
Journal | Journal of Organic Chemistry |
Volume | 84 |
Issue number | 7 |
Early online date | 13 Mar 2019 |
DOIs | |
Publication status | Published - 5 Apr 2019 |
Keywords
- Functionalization
- Nanofibers
- Peptides and proteins
- Scaffolds
- Substituents
ASJC Scopus subject areas
- Organic Chemistry