Pyridinone and Pyrimidinone Derivatives as Factor XIa Inhibitors

Steve Courtney; Chris Yarnold; Stuart Flanagan; Gareth Brace; John Barker; Osamyu Ichihara; Elise Gadouleau; Anthony Richardson; Takashi Kondo; Akira Imagawa; Shingo Nakatani; Ryo Suzuki; Sho Kouyama

Pyridinone and Pyrimidinone Derivatives as Factor XIa Inhibitors

Steve Courtney (Inventor), Chris Yarnold (Inventor), Stuart Flanagan (Inventor), Gareth Brace (Inventor), John Barker (Inventor), Osamyu Ichihara (Inventor), Elise Gadouleau (Inventor), Anthony Richardson (Inventor), Takashi Kondo (Inventor), Akira Imagawa (Inventor), Shingo Nakatani (Inventor), Ryo Suzuki (Inventor), Sho Kouyama (Inventor)

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Abstract

The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.

Original language	English
Patent number	WO/2013/093484
IPC	C07D 401/14 2006.1,C07D 471/04 2006.1,C07D 487/04 2006.1,A61K 31/437 2006.1,A61K 31/519 2006.1,A61P 9/00 2006.1
Priority date	21/12/11
Filing date	20/12/12
Publication status	Published - 27 Jun 2013

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WO 2013/093484 A1Final published version, 24 MB

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title = "Pyridinone and Pyrimidinone Derivatives as Factor XIa Inhibitors",

abstract = "The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.",

author = "Steve Courtney and Chris Yarnold and Stuart Flanagan and Gareth Brace and John Barker and Osamyu Ichihara and Elise Gadouleau and Anthony Richardson and Takashi Kondo and Akira Imagawa and Shingo Nakatani and Ryo Suzuki and Sho Kouyama",

year = "2013",

month = jun,

day = "27",

language = "English",

type = "Patent",

note = "WO/2013/093484; C07D 401/14 2006.1,C07D 471/04 2006.1,C07D 487/04 2006.1,A61K 31/437 2006.1,A61K 31/519 2006.1,A61P 9/00 2006.1",

}

TY - PAT

T1 - Pyridinone and Pyrimidinone Derivatives as Factor XIa Inhibitors

AU - Courtney, Steve

AU - Yarnold, Chris

AU - Flanagan, Stuart

AU - Brace, Gareth

AU - Barker, John

AU - Ichihara, Osamyu

AU - Gadouleau, Elise

AU - Richardson, Anthony

AU - Kondo, Takashi

AU - Imagawa, Akira

AU - Nakatani, Shingo

AU - Suzuki, Ryo

AU - Kouyama, Sho

PY - 2013/6/27

Y1 - 2013/6/27

N2 - The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.

AB - The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.

UR - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013093484&_cid=P10-KXITIJ-44122-1

M3 - Patent

M1 - WO/2013/093484

Y2 - 2012/12/20

ER -

Pyridinone and Pyrimidinone Derivatives as Factor XIa Inhibitors

Abstract

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