Pyridinone and Pyrimidinone Derivatives as Factor XIa Inhibitors

Steve Courtney (Inventor), Chris Yarnold (Inventor), Stuart Flanagan (Inventor), Gareth Brace (Inventor), John Barker (Inventor), Osamyu Ichihara (Inventor), Elise Gadouleau (Inventor), Anthony Richardson (Inventor), Takashi Kondo (Inventor), Akira Imagawa (Inventor), Shingo Nakatani (Inventor), Ryo Suzuki (Inventor), Sho Kouyama (Inventor)

Research output: Patent

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Abstract

The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.
Original languageEnglish
Patent numberWO/2013/093484
IPCC07D 401/14 2006.1,C07D 471/04 2006.1,C07D 487/04 2006.1,A61K 31/437 2006.1,A61K 31/519 2006.1,A61P 9/00 2006.1
Priority date21/12/11
Filing date20/12/12
Publication statusPublished - 27 Jun 2013

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