QT dispersion in patients with chronic heart failure

β blockers are associated with a reduction in QT dispersion

C. E. Bonnar, A. P. Davie, L. Caruana, L. Fenn, S. A. Ogston, J. J. V. McMurray, A. D. Struthers

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Abstract

    OBJECTIVE To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function.

    DESIGN A retrospective, case-control study with controls matched 4:1 for age, sex, previous myocardial infarction, and diuretic and ß?blocker treatment.

    SETTING A regional cardiology centre and a university teaching hospital.

    PATIENTS 25 patients with impaired left ventricular systolic function and 100 patients with normal left ventricular systolic function.

    MAIN OUTCOME MEASURES QT and QTc dispersion measured by three methods: the difference between maximum and minimum QT and QTc intervals, the standard deviation of QT and QTc intervals, and the “lead adjusted” QT and QTc dispersion.

    RESULTS All measures of QT/QTc dispersion were closely interrelated (r values 0.86 to 0.99; all p?<?0.001). All measures of QT and QTc dispersion were significantly increased in the patients with impaired left ventricular systolic functionv controls (p?<?0.001): 71.9 (6.5) (mean (SEM)) v 46.9 (1.7) ms for QT dispersion, and 83.6 (7.6) v 54.3 (2.1) ms-1-2 for QTc dispersion. All six dispersion parameters were reduced in patients taking ß?blockers (p?<?0.05), regardless of whether left ventricular function was normal or impaired—by 9.4 (4.6) ms for QT dispersion (p?<?0.05) and by 13.8 (6.5) ms-1-2 for QTc dispersion (p?=?0.01).

    CONCLUSIONS QT and QTc dispersion are increased in patients with systolic heart failure in comparison with matched controls, regardless of the method of measurement and independently of possible confounding factors. ß?Blockers are associated with a reduction in both QT and QTc dispersion, raising the possibility that a reduction in dispersion of ventricular repolarisation may be an important antiarrhythmic mechanism of ß blockade.

    Original languageEnglish
    Pages (from-to)297-302
    Number of pages6
    JournalHeart (British Cardiac Society)
    Volume81
    Issue number3
    DOIs
    Publication statusPublished - 1999

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    Heart Failure
    Left Ventricular Function
    Systolic Heart Failure
    Cardiology
    Diuretics
    Teaching Hospitals
    Case-Control Studies
    Myocardial Infarction

    Cite this

    Bonnar, C. E. ; Davie, A. P. ; Caruana, L. ; Fenn, L. ; Ogston, S. A. ; McMurray, J. J. V. ; Struthers, A. D. / QT dispersion in patients with chronic heart failure : β blockers are associated with a reduction in QT dispersion. In: Heart (British Cardiac Society). 1999 ; Vol. 81, No. 3. pp. 297-302.
    @article{85384ce6363547da81ca486a5dec76cb,
    title = "QT dispersion in patients with chronic heart failure: β blockers are associated with a reduction in QT dispersion",
    abstract = "OBJECTIVE To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function. DESIGN A retrospective, case-control study with controls matched 4:1 for age, sex, previous myocardial infarction, and diuretic and {\ss}?blocker treatment. SETTING A regional cardiology centre and a university teaching hospital. PATIENTS 25 patients with impaired left ventricular systolic function and 100 patients with normal left ventricular systolic function. MAIN OUTCOME MEASURES QT and QTc dispersion measured by three methods: the difference between maximum and minimum QT and QTc intervals, the standard deviation of QT and QTc intervals, and the “lead adjusted” QT and QTc dispersion. RESULTS All measures of QT/QTc dispersion were closely interrelated (r values 0.86 to 0.99; all p?<?0.001). All measures of QT and QTc dispersion were significantly increased in the patients with impaired left ventricular systolic functionv controls (p?<?0.001): 71.9 (6.5) (mean (SEM)) v 46.9 (1.7) ms for QT dispersion, and 83.6 (7.6) v 54.3 (2.1) ms-1-2 for QTc dispersion. All six dispersion parameters were reduced in patients taking {\ss}?blockers (p?<?0.05), regardless of whether left ventricular function was normal or impaired—by 9.4 (4.6) ms for QT dispersion (p?<?0.05) and by 13.8 (6.5) ms-1-2 for QTc dispersion (p?=?0.01). CONCLUSIONS QT and QTc dispersion are increased in patients with systolic heart failure in comparison with matched controls, regardless of the method of measurement and independently of possible confounding factors. {\ss}?Blockers are associated with a reduction in both QT and QTc dispersion, raising the possibility that a reduction in dispersion of ventricular repolarisation may be an important antiarrhythmic mechanism of {\ss} blockade.",
    author = "Bonnar, {C. E.} and Davie, {A. P.} and L. Caruana and L. Fenn and Ogston, {S. A.} and McMurray, {J. J. V.} and Struthers, {A. D.}",
    year = "1999",
    doi = "10.1136/hrt.81.3.297",
    language = "English",
    volume = "81",
    pages = "297--302",
    journal = "Heart",
    issn = "1355-6037",
    publisher = "BMJ Publishing Group",
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    QT dispersion in patients with chronic heart failure : β blockers are associated with a reduction in QT dispersion. / Bonnar, C. E.; Davie, A. P.; Caruana, L.; Fenn, L.; Ogston, S. A.; McMurray, J. J. V.; Struthers, A. D.

    In: Heart (British Cardiac Society), Vol. 81, No. 3, 1999, p. 297-302.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - QT dispersion in patients with chronic heart failure

    T2 - β blockers are associated with a reduction in QT dispersion

    AU - Bonnar, C. E.

    AU - Davie, A. P.

    AU - Caruana, L.

    AU - Fenn, L.

    AU - Ogston, S. A.

    AU - McMurray, J. J. V.

    AU - Struthers, A. D.

    PY - 1999

    Y1 - 1999

    N2 - OBJECTIVE To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function. DESIGN A retrospective, case-control study with controls matched 4:1 for age, sex, previous myocardial infarction, and diuretic and ß?blocker treatment. SETTING A regional cardiology centre and a university teaching hospital. PATIENTS 25 patients with impaired left ventricular systolic function and 100 patients with normal left ventricular systolic function. MAIN OUTCOME MEASURES QT and QTc dispersion measured by three methods: the difference between maximum and minimum QT and QTc intervals, the standard deviation of QT and QTc intervals, and the “lead adjusted” QT and QTc dispersion. RESULTS All measures of QT/QTc dispersion were closely interrelated (r values 0.86 to 0.99; all p?<?0.001). All measures of QT and QTc dispersion were significantly increased in the patients with impaired left ventricular systolic functionv controls (p?<?0.001): 71.9 (6.5) (mean (SEM)) v 46.9 (1.7) ms for QT dispersion, and 83.6 (7.6) v 54.3 (2.1) ms-1-2 for QTc dispersion. All six dispersion parameters were reduced in patients taking ß?blockers (p?<?0.05), regardless of whether left ventricular function was normal or impaired—by 9.4 (4.6) ms for QT dispersion (p?<?0.05) and by 13.8 (6.5) ms-1-2 for QTc dispersion (p?=?0.01). CONCLUSIONS QT and QTc dispersion are increased in patients with systolic heart failure in comparison with matched controls, regardless of the method of measurement and independently of possible confounding factors. ß?Blockers are associated with a reduction in both QT and QTc dispersion, raising the possibility that a reduction in dispersion of ventricular repolarisation may be an important antiarrhythmic mechanism of ß blockade.

    AB - OBJECTIVE To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function. DESIGN A retrospective, case-control study with controls matched 4:1 for age, sex, previous myocardial infarction, and diuretic and ß?blocker treatment. SETTING A regional cardiology centre and a university teaching hospital. PATIENTS 25 patients with impaired left ventricular systolic function and 100 patients with normal left ventricular systolic function. MAIN OUTCOME MEASURES QT and QTc dispersion measured by three methods: the difference between maximum and minimum QT and QTc intervals, the standard deviation of QT and QTc intervals, and the “lead adjusted” QT and QTc dispersion. RESULTS All measures of QT/QTc dispersion were closely interrelated (r values 0.86 to 0.99; all p?<?0.001). All measures of QT and QTc dispersion were significantly increased in the patients with impaired left ventricular systolic functionv controls (p?<?0.001): 71.9 (6.5) (mean (SEM)) v 46.9 (1.7) ms for QT dispersion, and 83.6 (7.6) v 54.3 (2.1) ms-1-2 for QTc dispersion. All six dispersion parameters were reduced in patients taking ß?blockers (p?<?0.05), regardless of whether left ventricular function was normal or impaired—by 9.4 (4.6) ms for QT dispersion (p?<?0.05) and by 13.8 (6.5) ms-1-2 for QTc dispersion (p?=?0.01). CONCLUSIONS QT and QTc dispersion are increased in patients with systolic heart failure in comparison with matched controls, regardless of the method of measurement and independently of possible confounding factors. ß?Blockers are associated with a reduction in both QT and QTc dispersion, raising the possibility that a reduction in dispersion of ventricular repolarisation may be an important antiarrhythmic mechanism of ß blockade.

    U2 - 10.1136/hrt.81.3.297

    DO - 10.1136/hrt.81.3.297

    M3 - Article

    VL - 81

    SP - 297

    EP - 302

    JO - Heart

    JF - Heart

    SN - 1355-6037

    IS - 3

    ER -