QT dispersion in patients with chronic heart failure: β blockers are associated with a reduction in QT dispersion

C. E. Bonnar, A. P. Davie, L. Caruana, L. Fenn, S. A. Ogston, J. J. V. McMurray, A. D. Struthers

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Abstract

    OBJECTIVE To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function.

    DESIGN A retrospective, case-control study with controls matched 4:1 for age, sex, previous myocardial infarction, and diuretic and ß?blocker treatment.

    SETTING A regional cardiology centre and a university teaching hospital.

    PATIENTS 25 patients with impaired left ventricular systolic function and 100 patients with normal left ventricular systolic function.

    MAIN OUTCOME MEASURES QT and QTc dispersion measured by three methods: the difference between maximum and minimum QT and QTc intervals, the standard deviation of QT and QTc intervals, and the “lead adjusted” QT and QTc dispersion.

    RESULTS All measures of QT/QTc dispersion were closely interrelated (r values 0.86 to 0.99; all p?<?0.001). All measures of QT and QTc dispersion were significantly increased in the patients with impaired left ventricular systolic functionv controls (p?<?0.001): 71.9 (6.5) (mean (SEM)) v 46.9 (1.7) ms for QT dispersion, and 83.6 (7.6) v 54.3 (2.1) ms-1-2 for QTc dispersion. All six dispersion parameters were reduced in patients taking ß?blockers (p?<?0.05), regardless of whether left ventricular function was normal or impaired—by 9.4 (4.6) ms for QT dispersion (p?<?0.05) and by 13.8 (6.5) ms-1-2 for QTc dispersion (p?=?0.01).

    CONCLUSIONS QT and QTc dispersion are increased in patients with systolic heart failure in comparison with matched controls, regardless of the method of measurement and independently of possible confounding factors. ß?Blockers are associated with a reduction in both QT and QTc dispersion, raising the possibility that a reduction in dispersion of ventricular repolarisation may be an important antiarrhythmic mechanism of ß blockade.

    Original languageEnglish
    Pages (from-to)297-302
    Number of pages6
    JournalHeart (British Cardiac Society)
    Volume81
    Issue number3
    DOIs
    Publication statusPublished - 1999

    Fingerprint Dive into the research topics of 'QT dispersion in patients with chronic heart failure: β blockers are associated with a reduction in QT dispersion'. Together they form a unique fingerprint.

  • Cite this