Quantification of cytochrome P450 reductase gene expression in human tissues

TY - JOUR

T1 - Quantification of cytochrome P450 reductase gene expression in human tissues

AU - Shephard, Elizabeth A.

AU - Palmer, Colin N.A.

AU - Segall, H. J.

AU - Phillips, Ian R.

PY - 1992/4

Y1 - 1992/4

N2 - We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little interindividual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.

AB - We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little interindividual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.

UR - https://www.scopus.com/pages/publications/0026572114

U2 - 10.1016/0003-9861(92)90152-M

DO - 10.1016/0003-9861(92)90152-M

M3 - Article

C2 - 1550342

AN - SCOPUS:0026572114

SN - 0003-9861

VL - 294

SP - 168

EP - 172

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

IS - 1

ER -