Quantifying and Assessing Variations in the Intervertebral Foramen of L4-L5 Vertebrae using Magnetic Resonance Imaging

Amierul Bin Sharudin, Husni Ahmed Al-Goshae, Manah Changmai (Lead / Corresponding author), Hassan Ads, Mohammed Faez Baobaid, Abdulah Y. Al-Mahdi, Rajesh Thangarajan, Mahfoud A.M. Abdulghan, Sakina Ruhi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The primary objective of this study is to examine the relationship between the shape and size to age and sex of the L4/L5 intervertebral foramen, using a morphometric approach to enhance understanding of these associations.

Design: It is a retrospective cross-sectional study.

Materials and Method: The relevant data for the morphometric analysis includes MRI images of the lumbar spine. This study is divided into two parts: a reliability study and a subject study. Horos software was used to measure the intervertebral foramen (IVF) with the MRI images retrieved via DICOM.

Result: The investigation revealed a strong positive correlation between RW2 and RW3 (r = 0.889, p < 0.01), followed by LW2 and LW3 (r = 0.887, p < 0.01), indicating that these dimensions vary significantly. RH1 shows a statistically significant difference between genders, with p < 0.001. The chi-square test for the RIVF shapes revealed a Pearson value of 17.610 with 3 degrees of freedom and an asymptotic significance (2-sided) of less than 0.001.

Discussion: These findings are consistent with the literature on degenerative changes in the spinal structure. The strong positive correlations among the dimensions of the IVF suggest a degree of bilateral symmetry or mutual influence, which could be of interest for further anatomical and clinical studies.

Conclusion: The results revealed significant age and sex disparities in the intervertebral foramen. This study clarifies the anatomical variations in the lumbar region between sexes and contributes to a better understanding of spinal disorders.
Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalInternational Medical Journal
Volume32
Issue number1
Publication statusPublished - Mar 2025

Keywords

  • MRI
  • lumbar L4/L5
  • intervertebral foramen (IVF)
  • morphometric analysis

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