Keyphrases
Mathematical Modeling
100%
ERK Activity
100%
MEK-ERK
100%
BRAF V600E
100%
Dabrafenib
100%
ERK Cascade
100%
Trametinib
80%
Vertical Inhibition
60%
Chemical Reaction
40%
Molecular Mechanism
40%
Drug Resistance
40%
Standard of Care
20%
Computational Simulation
20%
Cell Proliferation
20%
Ordinary Differential Equations
20%
Temporal Evolution
20%
Multiple Components
20%
Melanoma
20%
In Vitro Data
20%
ERK Pathway
20%
Quantitative Methods
20%
Dual Inhibition
20%
Signaling Dynamics
20%
Melanoma Cells
20%
ATP Level
20%
Mechanistic Mathematical Models
20%
BRAF Inhibitor (BRAFi)
20%
Component Concentration
20%
BRAF-mutant Melanoma
20%
Mutant BRAF
20%
MEK Inhibitor (MEKi)
20%
BRAF V600E mutant
20%
Dose Combination
20%
Mass-action Kinetics
20%
Biochemistry, Genetics and Molecular Biology
Dabrafenib
100%
Trametinib
80%
Drug Resistance
40%
Dynamics
20%
Cell Proliferation
20%
Adenosine Triphosphate
20%
Quantitative Technique
20%
MEK Inhibitor
20%
Mass Action
20%
Pharmacology, Toxicology and Pharmaceutical Science
Dabrafenib
100%
Trametinib
80%
Melanoma
60%
Drug Resistance
40%
Adenosine Triphosphate
20%
Mitogen Activated Protein Kinase Kinase Inhibitor
20%
Chemistry
Dabrafenib
100%
Trametinib
80%
ATP
20%
EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor
20%