Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

Guangying Guan, Chunhui Li, Yuting Ling, Ying Yang, Jan B. Vorstius, Robert P. Keatch, Ruikang K. Wang, Zhihong Huang (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)
65 Downloads (Pure)

Abstract

Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases.
Original languageEnglish
Article number111417
Number of pages7
JournalJournal of Biomedical Optics
Volume18
Issue number11
Early online date5 Nov 2013
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Elastography
  • Optical coherence tomography
  • Acoustics
  • Tissues
  • Magnesium
  • Biomedical optics
  • Coherence (optics)
  • Signal detection
  • Collagen
  • Ultrasonography

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