Quantitative measurement and real-time tracking of high intensity focused ultrasound using phase-sensitive optical coherence tomography: feasibility study

Nhan Le (Lead / Corresponding author), ShaoZhen Song, Ghulam Nabi, Ruikang Wang, Zhihong Huang

    Research output: Contribution to journalArticle

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    Abstract

    PURPOSE: Phase-sensitive optical coherence tomography (PhS-OCT) is proposed, as a new high intensity focused ultrasound (HIFU) imaging guidance to detect and track HIFU focus inside 1% agar samples in this work. The experiments studied the effect of varying HIFU power on the induction of shear wave, which can be implemented as a new technique to monitor focused ultrasound surgery (FUS).

    METHOD: A miniature HIFU transducer (1.02 MHz, 20 mm aperture diameter, 15 mm radius of curvature) was produced in-house, pressure-field mapped, and calibrated. The transducer was then embedded inside a 1% agar phantom, which was placed under PhS-OCT for observation, under various HIFU power settings (acoustic power, and number of cycles per pulse). Shear wave was induced on the sample surface by HIFU and was captured in full under PhS-OCT. The lowest HIFU acoustic power output for the detection of shear wave was found to be 0.36 W (1.02 MHz, 100 cycles/pulse), or with the number of cycles/pulse as low as 20 (1.02 MHz, 0.98 W acoustic power output).

    RESULTS: A linear relationship between acoustic power output and the maximum shear wave displacement was found in the first study. The second study explores a non-linear correlation between the (HIFU) numbers of cycles per pulse, and the maximum shear wave displacement.

    CONCLUSION: PhS-OCT demonstrates excellent tracking and detection of HIFU-induced shear wave. The results could benefit other imaging techniques in tracking and guiding HIFU focus. Further studies will explore the relationship between the physical transducer characteristics and the HIFU-induced shear wave.

    Original languageEnglish
    Pages (from-to)713-722
    Number of pages10
    JournalInternational Journal of Hyperthermia
    Volume32
    Issue number6
    Early online date5 Jul 2016
    DOIs
    Publication statusPublished - 17 Aug 2016

    Keywords

    • Acoustic radiation force impulse
    • high intensity focused ultrasound
    • shearwave imaging
    • ultrasound

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  • Student Theses

    Shear-wave imaging guidance for high-intensity focused ultrasound therapy

    Author: Le, M., 2019

    Supervisor: Huang, Z. (Supervisor) & Nabi, G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Profiles

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    Huang, Zhihong

    Person: Academic

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