Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

Richard McCulloch; Mark C. Field

doi:10.1016/j.pt.2015.05.001

Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

Richard McCulloch, Mark C. Field (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Antigenic variation is central to the virulence of African trypanosomes, where the VSG coat is used to evade the host immune system. Recent advances in technology have now allowed more secrets of this system to emerge, with the surprising insight that a broad repertoire of VSGs is rapidly expressed. This has major implications for how the parasite must evade the host immune response.

Original language	English
Pages (from-to)	346-349
Number of pages	4
Journal	Trends in Parasitology
Volume	31
Issue number	8
Early online date	18 May 2015
DOIs	https://doi.org/10.1016/j.pt.2015.05.001
Publication status	Published - Aug 2015

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10.1016/j.pt.2015.05.001

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title = "Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei",

abstract = "Antigenic variation is central to the virulence of African trypanosomes, where the VSG coat is used to evade the host immune system. Recent advances in technology have now allowed more secrets of this system to emerge, with the surprising insight that a broad repertoire of VSGs is rapidly expressed. This has major implications for how the parasite must evade the host immune response.",

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AB - Antigenic variation is central to the virulence of African trypanosomes, where the VSG coat is used to evade the host immune system. Recent advances in technology have now allowed more secrets of this system to emerge, with the surprising insight that a broad repertoire of VSGs is rapidly expressed. This has major implications for how the parasite must evade the host immune response.

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Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei

Abstract

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