Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

Shaozhen Song, Nhan Minh Le, Ruikang K. Wang, Zhihong Huang (Lead / Corresponding author)

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    4 Citations (Scopus)


    Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as limited wave propagation range and/or difficulties in non-invasive scans requiring precisions, accuracy. Thus, we propose linear phase array ultrasound transducer as a remote wave source, combined with the high-speed, 47,000-frame-per-second Shear-wave visualization provided by phase-sensitive OCT. In this study, we observed for the first time shear waves induced by a 128 element linear array ultrasound imaging transducer, while the ultrasound and OCT images (within the OCE detection range) were triggered simultaneously. Acoustic radiation force impulses are induced by emitting 10 MHz tone-bursts of sub-millisecond durations (between 50 μm - 100 μm). Ultrasound beam steering is achieved by programming appropriate phase delay, covering a lateral range of 10 mm and full OCT axial (depth) range in the imaging sample. Tissue-mimicking phantoms with agarose concentration of 0.5% and 1% was used in the SW-OCE measurements as the only imaging samples. The results shows extensive improvements over the range of SW-OCE elasticity map; such improvements can also be seen over Shear-wave Velocities in softer and stiffer phantoms, as well as determining the boundary of multiple inclusions with different stiffness. This approach opens up the feasibility to combine medical ultrasound imaging and SW-OCE for high-resolution localized quantitative measurement of tissue biomechanical property.

    Original languageEnglish
    Title of host publicationOptical Elastography and Tissue Biomechanics II
    EditorsKirill V. Larin, David D. Sampson
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628414172
    Publication statusPublished - 2015
    EventSPIE Photonics West 2015: Optical Elastography and Tissue Biomechanics II - Moscone Center, San Francisco, United States
    Duration: 7 Feb 20158 Feb 2015

    Publication series

    NameProceedings of SPIE
    NameProgress in Biomedical Optics and Imaging


    ConferenceSPIE Photonics West 2015: Optical Elastography and Tissue Biomechanics II
    Country/TerritoryUnited States
    CitySan Francisco
    Internet address


    • Acoustic radiation force impulse
    • Optical Coherence Elastography
    • Shear wave imaging

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging


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