Abstract
Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as limited wave propagation range and/or difficulties in non-invasive scans requiring precisions, accuracy. Thus, we propose linear phase array ultrasound transducer as a remote wave source, combined with the high-speed, 47,000-frame-per-second Shear-wave visualization provided by phase-sensitive OCT. In this study, we observed for the first time shear waves induced by a 128 element linear array ultrasound imaging transducer, while the ultrasound and OCT images (within the OCE detection range) were triggered simultaneously. Acoustic radiation force impulses are induced by emitting 10 MHz tone-bursts of sub-millisecond durations (between 50 μm - 100 μm). Ultrasound beam steering is achieved by programming appropriate phase delay, covering a lateral range of 10 mm and full OCT axial (depth) range in the imaging sample. Tissue-mimicking phantoms with agarose concentration of 0.5% and 1% was used in the SW-OCE measurements as the only imaging samples. The results shows extensive improvements over the range of SW-OCE elasticity map; such improvements can also be seen over Shear-wave Velocities in softer and stiffer phantoms, as well as determining the boundary of multiple inclusions with different stiffness. This approach opens up the feasibility to combine medical ultrasound imaging and SW-OCE for high-resolution localized quantitative measurement of tissue biomechanical property.
Original language | English |
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Title of host publication | Optical Elastography and Tissue Biomechanics II |
Editors | Kirill V. Larin, David D. Sampson |
Place of Publication | Bellingham |
Publisher | SPIE-International Society for Optical Engineering |
ISBN (Print) | 9781628414172 |
DOIs | |
Publication status | Published - 2015 |
Event | SPIE Photonics West 2015: Optical Elastography and Tissue Biomechanics II - Moscone Center, San Francisco, United States Duration: 7 Feb 2015 → 8 Feb 2015 http://spie.org/x112639.xml |
Publication series
Name | Proceedings of SPIE |
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Publisher | SPIE |
Volume | 9327 |
Name | Progress in Biomedical Optics and Imaging |
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Publisher | SPIE |
Number | 25 |
Volume | 16 |
Conference
Conference | SPIE Photonics West 2015: Optical Elastography and Tissue Biomechanics II |
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Country/Territory | United States |
City | San Francisco |
Period | 7/02/15 → 8/02/15 |
Internet address |
Keywords
- Acoustic radiation force impulse
- Optical Coherence Elastography
- Shear wave imaging
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
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Dive into the research topics of 'Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer'. Together they form a unique fingerprint.Student theses
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Shear-wave imaging guidance for high-intensity focused ultrasound therapy
Le, M. (Author), Huang, Z. (Supervisor) & Nabi, G. (Supervisor), 2019Student thesis: Doctoral Thesis › Doctor of Philosophy