Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Paul R. Clarke (Lead / Corresponding author), Chuanmao Zhang

    Research output: Contribution to journalReview articlepeer-review

    114 Citations (Scopus)

    Abstract

    Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in mitotic spindle assembly and nuclear envelope (NE) formation in vitro. During Savespindle assembly, Ran controls the formation of complexes with importins, the same effectors that control nucleocytoplasmic transport. Here, we review these advances and discuss a general model for Ran in the coordination of nuclear processes throughout the cell division cycle via common biochemical mechanisms.

    Original languageEnglish
    Pages (from-to)366-371
    Number of pages6
    JournalTrends in Cell Biology
    Volume11
    Issue number9
    Early online date14 Aug 2001
    DOIs
    Publication statusPublished - 1 Sept 2001

    ASJC Scopus subject areas

    • Cell Biology

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