TY - JOUR
T1 - Ran GTPase
T2 - A master regulator of nuclear structure and function during the eukaryotic cell division cycle?
AU - Clarke, Paul R.
AU - Zhang, Chuanmao
PY - 2001/9/1
Y1 - 2001/9/1
N2 - Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in mitotic spindle assembly and nuclear envelope (NE) formation in vitro. During Savespindle assembly, Ran controls the formation of complexes with importins, the same effectors that control nucleocytoplasmic transport. Here, we review these advances and discuss a general model for Ran in the coordination of nuclear processes throughout the cell division cycle via common biochemical mechanisms.
AB - Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in mitotic spindle assembly and nuclear envelope (NE) formation in vitro. During Savespindle assembly, Ran controls the formation of complexes with importins, the same effectors that control nucleocytoplasmic transport. Here, we review these advances and discuss a general model for Ran in the coordination of nuclear processes throughout the cell division cycle via common biochemical mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=0035445281&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(01)02071-2
DO - 10.1016/S0962-8924(01)02071-2
M3 - Review article
C2 - 11514190
AN - SCOPUS:0035445281
VL - 11
SP - 366
EP - 371
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 9
ER -