Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?

Paul R. Clarke (Lead / Corresponding author), Chuanmao Zhang

Research output: Contribution to journalReview article

108 Citations (Scopus)

Abstract

Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in mitotic spindle assembly and nuclear envelope (NE) formation in vitro. During Savespindle assembly, Ran controls the formation of complexes with importins, the same effectors that control nucleocytoplasmic transport. Here, we review these advances and discuss a general model for Ran in the coordination of nuclear processes throughout the cell division cycle via common biochemical mechanisms.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalTrends in Cell Biology
Volume11
Issue number9
Early online date14 Aug 2001
DOIs
Publication statusPublished - 1 Sep 2001

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