Randomised trial of oral aspirin for chronic venous leg ulcers

A.M. Layton, M.J.D Goodfield, S.H. Ibbotson, J.A. Davies

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    Abstract

    The effect of oral aspirin on the healing rate of chronic venous leg ulcers was compared with that of placebo in a double-blind randomised trial. 20 subjects with chronic venous leg ulcers were randomised to daily enteric-coated aspirin 300 mg or placebo, and standardised compression bandaging. 4 months of treatment achieved ulcer healing in 38% of the patients receiving aspirin compared with 0% of those receiving placebo (p <0.007). 52% of the aspirin-treated group showed significant reduction in ulcer size compared with 26% of placebo recipients (p <0.007). Reduction in ulcer surface area was significantly better in the aspirin-treated group at 2 (p <0.01) and 4 months (p <0.002) compared with that in the placebo group.
    Original languageEnglish
    Pages (from-to)164-165
    Number of pages2
    JournalLancet
    Volume344
    Issue number8916
    DOIs
    Publication statusPublished - 16 Jul 1994

    Keywords

    • Administration, Oral
    • Varicose Ulcer
    • Aspirin
    • Combined Modality Therapy
    • Aged, 80 and over
    • Humans
    • Aged
    • Middle Aged
    • Chronic Disease
    • Male
    • Female
    • Bandages

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