Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome

Satnam Singh; Roger Beadle; Donnie Cameron; Amelia Rudd; Maggie Bruce; Baljit Jagpal; Konstantin Schwarz; Gemma Brindley; Fergus Mckiddie; Chim Lang; Dana Dawson; Michael Frenneaux

doi:10.2217/fca.14.62

Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome

Satnam Singh, Roger Beadle, Donnie Cameron, Amelia Rudd, Maggie Bruce, Baljit Jagpal, Konstantin Schwarz, Gemma Brindley, Fergus Mckiddie, Chim Lang, Dana Dawson, Michael Frenneaux (Lead / Corresponding author)

University of Dundee

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.

Original language	English
Pages (from-to)	693-698
Number of pages	6
Journal	Future Cardiology
Volume	10
Issue number	6
DOIs	https://doi.org/10.2217/fca.14.62
Publication status	Published - 1 Nov 2014

Keywords

cardiac spectroscopy
diastole
ejection fraction
heart failure
perhexiline

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Molecular Medicine

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10.2217/fca.14.62

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AU - Cameron, Donnie

AU - Rudd, Amelia

AU - Bruce, Maggie

AU - Jagpal, Baljit

AU - Schwarz, Konstantin

AU - Brindley, Gemma

AU - Mckiddie, Fergus

AU - Lang, Chim

AU - Dawson, Dana

AU - Frenneaux, Michael

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AB - Recently heart failure with preserved ejection fraction (HFpEF) has emerged as a huge epidemic. Increasing evidence shows the role of energy deficiency in the pathophysiology of HFpEF. In the current study, we hypothesize that the use of metabolic modulator perhexiline would correct myocardial energy deficiency and improve exercise capacity and diastolic abnormalities in patients with this syndrome.

KW - cardiac spectroscopy

KW - diastole

KW - ejection fraction

KW - heart failure

KW - perhexiline

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Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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Erratum: Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome (Future Cardiology (2014) 10:6 (693-698))

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