Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line

Wafiya Jibrin; Rod T Mitchell; Federica Lopes

doi:10.1530/RAF-26-0044

Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line

Wafiya Jibrin
, Rod T Mitchell
, Federica Lopes (Lead / Corresponding author)

Research output: Contribution to journal › Letter › peer-review

9 Downloads (Pure)

Abstract

In the UK, every day about five children receive a diagnosis of cancer. Although the majority (over 80%) will survive, some will become infertile depending on the severity of the treatment received during childhood. Currently, there are no medical treatments available to protect male fertility. This study assessed if rapamycin, a drug currently used to treat other medical conditions, which has been shown in experimental studies to help protect female fertility from cancer treatment, could be used to protect male fertility. Results showed that rapamycin did not prevent overall loss and damage of the cells that will develop into sperm. Further studies are needed to find medical strategies to preserve young boys’ fertility.

Original language	English
Article number	RAF260044
Journal	Reproduction and Fertility
Volume	7
Issue number	3
Early online date	15 Jul 2026
DOIs	https://doi.org/10.1530/RAF-26-0044
Publication status	Published - Jul 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

chemotherapy
cisplatin
infertility
rapamycin

ASJC Scopus subject areas

Embryology
Reproductive Medicine
Obstetrics and Gynaecology
Urology

Access to Document

10.1530/RAF-26-0044Licence: CC BY

Final Published Version
This work is licensed under a Creative Commons Attribution 4.0 International License.
Final published version, 427 KBLicence: CC BY

Cite this

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title = "Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line",

abstract = "In the UK, every day about five children receive a diagnosis of cancer. Although the majority (over 80\%) will survive, some will become infertile depending on the severity of the treatment received during childhood. Currently, there are no medical treatments available to protect male fertility. This study assessed if rapamycin, a drug currently used to treat other medical conditions, which has been shown in experimental studies to help protect female fertility from cancer treatment, could be used to protect male fertility. Results showed that rapamycin did not prevent overall loss and damage of the cells that will develop into sperm. Further studies are needed to find medical strategies to preserve young boys{\textquoteright} fertility.",

keywords = "chemotherapy, cisplatin, infertility, rapamycin",

author = "Wafiya Jibrin and Mitchell, \{Rod T\} and Federica Lopes",

note = "Publisher Copyright: {\textcopyright} 2026 the author(s). This work is licensed under a Creative Commons Attribution 4.0 International License.",

year = "2026",

month = jul,

doi = "10.1530/RAF-26-0044",

language = "English",

volume = "7",

journal = "Reproduction and Fertility",

issn = "2633-8386",

publisher = "BioScientifica Ltd.",

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TY - JOUR

T1 - Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line

AU - Jibrin, Wafiya

AU - Mitchell, Rod T

AU - Lopes, Federica

PY - 2026/7

Y1 - 2026/7

N2 - In the UK, every day about five children receive a diagnosis of cancer. Although the majority (over 80%) will survive, some will become infertile depending on the severity of the treatment received during childhood. Currently, there are no medical treatments available to protect male fertility. This study assessed if rapamycin, a drug currently used to treat other medical conditions, which has been shown in experimental studies to help protect female fertility from cancer treatment, could be used to protect male fertility. Results showed that rapamycin did not prevent overall loss and damage of the cells that will develop into sperm. Further studies are needed to find medical strategies to preserve young boys’ fertility.

AB - In the UK, every day about five children receive a diagnosis of cancer. Although the majority (over 80%) will survive, some will become infertile depending on the severity of the treatment received during childhood. Currently, there are no medical treatments available to protect male fertility. This study assessed if rapamycin, a drug currently used to treat other medical conditions, which has been shown in experimental studies to help protect female fertility from cancer treatment, could be used to protect male fertility. Results showed that rapamycin did not prevent overall loss and damage of the cells that will develop into sperm. Further studies are needed to find medical strategies to preserve young boys’ fertility.

KW - chemotherapy

KW - cisplatin

KW - infertility

KW - rapamycin

UR - https://www.scopus.com/pages/publications/105046044315

U2 - 10.1530/RAF-26-0044

DO - 10.1530/RAF-26-0044

M3 - Letter

C2 - 42455795

SN - 2633-8386

VL - 7

JO - Reproduction and Fertility

JF - Reproduction and Fertility

IS - 3

M1 - RAF260044

ER -

Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Characterization Of Cell Cycle Check Points And DNA Damage Response Pathways In Spermatogonial Stem Cells After Chemotherapy Exposure As A Way To Reduce Genotoxic Damage (lead: University of Dundee other instns: University of Edinburgh, University Of Utah)

Cite this

Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Characterization Of Cell Cycle Check Points And DNA Damage Response Pathways In Spermatogonial Stem Cells After Chemotherapy Exposure As A Way To Reduce Genotoxic Damage (lead: University of Dundee other instns: University of Edinburgh, University Of Utah)

Cite this