Rapid dendritic and axonal responses to neuronal insults

Sarah M. Mizielinska, Sam M. Greenwood, Hemanth Tummala, Christopher N. Connolly

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system playing critical roles in basal synaptic transmission and mechanisms of learning and memory. Under normal conditions, glutamate is sequestered within synaptic vesicles (similar to 100 mm) with extracellular glutamate concentrations being limited (<1 mu M), via retrieval by plasma-membrane transporters on neuronal and glial cells. in the case of central nervous system trauma, stroke, epilepsy, and in certain neurodegenerative diseases, increased concentrations of extracellular glutamate (by vesicular release, cell lysis and/or decreased glutamate transporter uptake/feversal) stimulate the overactivation of local ionotropic glutamate receptors that trigger neuronal cell death (excitotoxicity). Other natural agonists, such as domoic acid, alcohol and auto-antibodies, have also been reported to induce excitotoxicity.

    Original languageEnglish
    Pages (from-to)1389-1393
    Number of pages5
    JournalBiochemical Society Transactions
    Volume37
    DOIs
    Publication statusPublished - Dec 2009

    Keywords

    • dendrite
    • dendritic bead
    • excitotoxicity
    • glutamate
    • mitochondrion
    • spine
    • GLUTAMATE-RECEPTOR ACTIVATION
    • ACUTE HIPPOCAMPAL SLICES
    • MITOCHONDRIAL TRANSPORT
    • NEURITIC DEGENERATION
    • MORPHOLOGICAL-CHANGES
    • EXCITOTOXIC INJURY
    • FOREBRAIN NEURONS
    • CULTURED NEURONS
    • TRANSGENIC MICE
    • KAINIC ACID

    Cite this

    Mizielinska, Sarah M. ; Greenwood, Sam M. ; Tummala, Hemanth ; Connolly, Christopher N. / Rapid dendritic and axonal responses to neuronal insults. In: Biochemical Society Transactions. 2009 ; Vol. 37. pp. 1389-1393.
    @article{3267bd261c914f74a2de1b96a0da93fd,
    title = "Rapid dendritic and axonal responses to neuronal insults",
    abstract = "Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system playing critical roles in basal synaptic transmission and mechanisms of learning and memory. Under normal conditions, glutamate is sequestered within synaptic vesicles (similar to 100 mm) with extracellular glutamate concentrations being limited (<1 mu M), via retrieval by plasma-membrane transporters on neuronal and glial cells. in the case of central nervous system trauma, stroke, epilepsy, and in certain neurodegenerative diseases, increased concentrations of extracellular glutamate (by vesicular release, cell lysis and/or decreased glutamate transporter uptake/feversal) stimulate the overactivation of local ionotropic glutamate receptors that trigger neuronal cell death (excitotoxicity). Other natural agonists, such as domoic acid, alcohol and auto-antibodies, have also been reported to induce excitotoxicity.",
    keywords = "dendrite, dendritic bead, excitotoxicity, glutamate, mitochondrion, spine, GLUTAMATE-RECEPTOR ACTIVATION, ACUTE HIPPOCAMPAL SLICES, MITOCHONDRIAL TRANSPORT, NEURITIC DEGENERATION, MORPHOLOGICAL-CHANGES, EXCITOTOXIC INJURY, FOREBRAIN NEURONS, CULTURED NEURONS, TRANSGENIC MICE, KAINIC ACID",
    author = "Mizielinska, {Sarah M.} and Greenwood, {Sam M.} and Hemanth Tummala and Connolly, {Christopher N.}",
    year = "2009",
    month = "12",
    doi = "10.1042/BST0371389",
    language = "English",
    volume = "37",
    pages = "1389--1393",
    journal = "Biochemical Society Transactions",
    issn = "0300-5127",
    publisher = "Portland Press",

    }

    Rapid dendritic and axonal responses to neuronal insults. / Mizielinska, Sarah M.; Greenwood, Sam M.; Tummala, Hemanth; Connolly, Christopher N.

    In: Biochemical Society Transactions, Vol. 37, 12.2009, p. 1389-1393.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Rapid dendritic and axonal responses to neuronal insults

    AU - Mizielinska, Sarah M.

    AU - Greenwood, Sam M.

    AU - Tummala, Hemanth

    AU - Connolly, Christopher N.

    PY - 2009/12

    Y1 - 2009/12

    N2 - Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system playing critical roles in basal synaptic transmission and mechanisms of learning and memory. Under normal conditions, glutamate is sequestered within synaptic vesicles (similar to 100 mm) with extracellular glutamate concentrations being limited (<1 mu M), via retrieval by plasma-membrane transporters on neuronal and glial cells. in the case of central nervous system trauma, stroke, epilepsy, and in certain neurodegenerative diseases, increased concentrations of extracellular glutamate (by vesicular release, cell lysis and/or decreased glutamate transporter uptake/feversal) stimulate the overactivation of local ionotropic glutamate receptors that trigger neuronal cell death (excitotoxicity). Other natural agonists, such as domoic acid, alcohol and auto-antibodies, have also been reported to induce excitotoxicity.

    AB - Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system playing critical roles in basal synaptic transmission and mechanisms of learning and memory. Under normal conditions, glutamate is sequestered within synaptic vesicles (similar to 100 mm) with extracellular glutamate concentrations being limited (<1 mu M), via retrieval by plasma-membrane transporters on neuronal and glial cells. in the case of central nervous system trauma, stroke, epilepsy, and in certain neurodegenerative diseases, increased concentrations of extracellular glutamate (by vesicular release, cell lysis and/or decreased glutamate transporter uptake/feversal) stimulate the overactivation of local ionotropic glutamate receptors that trigger neuronal cell death (excitotoxicity). Other natural agonists, such as domoic acid, alcohol and auto-antibodies, have also been reported to induce excitotoxicity.

    KW - dendrite

    KW - dendritic bead

    KW - excitotoxicity

    KW - glutamate

    KW - mitochondrion

    KW - spine

    KW - GLUTAMATE-RECEPTOR ACTIVATION

    KW - ACUTE HIPPOCAMPAL SLICES

    KW - MITOCHONDRIAL TRANSPORT

    KW - NEURITIC DEGENERATION

    KW - MORPHOLOGICAL-CHANGES

    KW - EXCITOTOXIC INJURY

    KW - FOREBRAIN NEURONS

    KW - CULTURED NEURONS

    KW - TRANSGENIC MICE

    KW - KAINIC ACID

    U2 - 10.1042/BST0371389

    DO - 10.1042/BST0371389

    M3 - Article

    C2 - 19909282

    VL - 37

    SP - 1389

    EP - 1393

    JO - Biochemical Society Transactions

    JF - Biochemical Society Transactions

    SN - 0300-5127

    ER -