Rapid prototyping manufacture of complex three dimensional microscaffolds used in regenerative medicine

K Donnelly, Robert Keatch, M S Pridham, B Collier, S L Schor, A. Schor, C Gribbon

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Extraordinary advances in cellular and molecular biology over the past few years have led to an enriched comprehension of the basic biological processes involved in wound healing. It is now recognised that cytokine-induced cell activation is profoundly influenced by both the biochemical and physical features of the macromolecular matrix. The focus of our research is to investigate the manner by which the matrix exerts this critical modulation of the wound healing response. For this purpose, solid freeform fabrication, rapid prototyping and soft lithography in combination with microfabrication techniques are used to generate 3-dimensional cell adhesion surfaces consisting of biologically relevant matrix molecules deposited with precisely defined micro-scale topological features.

    Original languageEnglish
    Title of host publication Rapid Design, Prototyping, and Manufacturing
    EditorsDM Jacobson, AEW Rennie, CE Bocking
    Place of PublicationWestminster
    PublisherProfessional Engineering Publishing Ltd
    Pages61-67
    Number of pages7
    ISBN (Print)1860584659
    Publication statusPublished - 2004
    Event5th National Conference on Rapid Design, Prototyping and Manufacturing - Lancaster, United Kingdom
    Duration: 28 May 200428 May 2004

    Conference

    Conference5th National Conference on Rapid Design, Prototyping and Manufacturing
    CountryUnited Kingdom
    CityLancaster
    Period28/05/0428/05/04

    Cite this

    Donnelly, K., Keatch, R., Pridham, M. S., Collier, B., Schor, S. L., Schor, A., & Gribbon, C. (2004). Rapid prototyping manufacture of complex three dimensional microscaffolds used in regenerative medicine. In DM. Jacobson, AEW. Rennie, & CE. Bocking (Eds.), Rapid Design, Prototyping, and Manufacturing (pp. 61-67). Professional Engineering Publishing Ltd .