Ras regulation and function in lymphocytes

Elisabeth Genot, Doreen A. Cantrell (Lead / Corresponding author)

    Research output: Contribution to journalReview article

    137 Citations (Scopus)

    Abstract

    The GTPase, Ras, is rapidly activated in antigen receptor stimulated T cells, B cells and mast cells. Ras can bind to diverse effector molecules when activated and thereby switch on multiple downstream effector pathways. In lymphocytes Ras plays an important role in the signalling pathways that activate transcription factors involved in cytokine gene induction. Ras is also a key component of the complex regulatory networks that control T and B cell development.

    Original languageEnglish
    Pages (from-to)289-294
    Number of pages6
    JournalCurrent Opinion in Immunology
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 1 Jun 2000

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