Ras regulation and function in lymphocytes

TY - JOUR

T1 - Ras regulation and function in lymphocytes

AU - Genot, Elisabeth

AU - Cantrell, Doreen A.

PY - 2000/6/1

Y1 - 2000/6/1

N2 - The GTPase, Ras, is rapidly activated in antigen receptor stimulated T cells, B cells and mast cells. Ras can bind to diverse effector molecules when activated and thereby switch on multiple downstream effector pathways. In lymphocytes Ras plays an important role in the signalling pathways that activate transcription factors involved in cytokine gene induction. Ras is also a key component of the complex regulatory networks that control T and B cell development.

AB - The GTPase, Ras, is rapidly activated in antigen receptor stimulated T cells, B cells and mast cells. Ras can bind to diverse effector molecules when activated and thereby switch on multiple downstream effector pathways. In lymphocytes Ras plays an important role in the signalling pathways that activate transcription factors involved in cytokine gene induction. Ras is also a key component of the complex regulatory networks that control T and B cell development.

UR - https://www.scopus.com/pages/publications/0034092777

U2 - 10.1016/S0952-7915(00)00089-3

DO - 10.1016/S0952-7915(00)00089-3

M3 - Review article

C2 - 10781411

AN - SCOPUS:0034092777

SN - 0952-7915

VL - 12

SP - 289

EP - 294

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 3

ER -