RAS testing of colorectal carcinoma: a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group

Newton A. C. S. Wong (Lead / Corresponding author), David Gonzalez (Lead / Corresponding author), Manuel Salto-Tellez (Lead / Corresponding author), Rachel Butler, Salvador J. Diaz-Cano, Mohammad Ilyas, William Newman, Emily Shaw, Philippe Taniere, Shaun V. Walsh

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    54 Citations (Scopus)

    Abstract

    Analysis of colorectal carcinoma (CRC) tissue for KRAS codon 12 or 13 mutations to guide use of anti-epidermal growth factor receptor (EGFR) therapy is now considered mandatory in the UK. The scope of this practice has been recently extended because of data indicating that NRAS mutations and additional KRAS mutations also predict for poor response to anti-EGFR therapy. The following document provides guidance on RAS (i.e., KRAS and NRAS) testing of CRC tissue in the setting of personalised medicine within the UK and particularly within the NHS. This guidance covers issues related to case selection, preanalytical aspects, analysis and interpretation of such RAS testing.

    Original languageEnglish
    Pages (from-to)751-757
    Number of pages7
    JournalJournal of Clinical Pathology
    Volume67
    Issue number9
    Early online date4 Jul 2014
    DOIs
    Publication statusPublished - Sep 2014

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    Wong, N. A. C. S., Gonzalez, D., Salto-Tellez, M., Butler, R., Diaz-Cano, S. J., Ilyas, M., Newman, W., Shaw, E., Taniere, P., & Walsh, S. V. (2014). RAS testing of colorectal carcinoma: a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group. Journal of Clinical Pathology, 67(9), 751-757. https://doi.org/10.1136/jclinpath-2014-202467