Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Niloufar Farzan, Susanne J. H. Vijverberg, Anand K. Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus Bønnelykke, Esteban G. Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C. Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M. Cloutier, Denis Daley, Herman T. Den Dekker, Nicole F. Dijk, Liesbeth DuijtsCarlos Flores, Erick Forno, Daniel B. Hawcutt, Natalia Hernandez-Pacheco, Johan C. de Jongste, Michael Kabesch, Gerard H. Koppelman, Vangelis G. Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N. Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnki, Jan A. M. Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L. Smyth, Csaba Szalai, Kelan G. Tantisira, Steve Turner, Marc P. van der Schee, Katia M. Verhamme, Anke Hilse Maitland-van der Zee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.

Materials & methods: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.

Results: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.

Conclusion: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

Original languageEnglish
JournalPharmacogenomics
Volume18
Issue number10
Early online date22 Jun 2017
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Asthma
  • Children
  • Consortium
  • Genetics
  • Pharmacogenomics
  • Treatment

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    Farzan, N., Vijverberg, S. J. H., Andiappan, A. K., Arianto, L., Berce, V., Blanca-López, N., Bisgaard, H., Bønnelykke, K., Burchard, E. G., Campo, P., Canino, G., Carleton, B., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Daley, D., Den Dekker, H. T., Dijk, N. F., ... Maitland-van der Zee, A. H. (2017). Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics, 18(10). https://doi.org/10.2217/pgs-2017-0035