A stratified approach to medicine aims to identify subgroups of patients who should be managed differently from others. Diabetes is a condition that offers considerable potential for stratification, in areas of drug response, complication risk and rate of progression amongst others. Approaches to stratification can be simple, using clinical phenotyping, or more complex involving genomic and other '-omic' technologies. In this review, I will highlight the utility of measuring endogenous insulin production to aid in diagnosis and appropriate treatment; outline key advances in monogenic diabetes where determining genetic aetiology can result in dramatic changes in treatment, and describe the developments in the field of pharmacogenetics in Type 2 diabetes. This article is protected by copyright. All rights reserved.
|Number of pages||6|
|Publication status||Published - Apr 2014|
|Event||Diabetes UK Professional Conference 2013 - Manchester Central Convention Complex, Manchester, United Kingdom|
Duration: 13 Mar 2013 → 15 Mar 2013
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RD Lawrence Lecture 2013
Pearson, Ewan (Recipient), 13 Mar 2013
Prize: Prize (including medals and awards)