Reactivity and Applications of Iodine Monochloride in Synthetic Approaches

David P. Day, Nawaf I. Alsenani, Abdulrahman A. Alsimaree

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Over the last half-decade, routes towards accessing halogenated compounds of value such as bioactive pharmaceuticals, organic building blocks has been of interest to the synthetic community. The demand for new methodologies to access important compounds has surged over the period. Amongst the halogenating agents available in a chemist's toolbox, one reagent in particular, iodine monochloride (ICl), is relatively under employed in comparison to alternatives such as molecular iodine for example. In this Minireview, we document the most recent applications (2015–2020) of ICl in synthetic organic transformations, namely halogenations including iodinations and chlorination reactions, cyclizations, metathesis reactions as well as oxidation processes. Furthermore, its versatile nature and interesting properties will be discussed, through its advantages and downfalls over other halogenating reagents, and discussions where relevant to compare modes of reactivity and mechanistic insights is presented.

Original languageEnglish
Pages (from-to)4299-4307
Number of pages9
JournalEuropean Journal of Organic Chemistry
Issue number30
Early online date31 May 2021
Publication statusPublished - 13 Aug 2021


  • Cyclization
  • Iodination
  • Iodine Monochloride Chlorination
  • Oxidation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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