'Real-life' reduction in cholesterol with statins, 1993 to 2002

Michael J. Murphy, Li Wei, Alexander D. Watson, Thomas M. MacDonald

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    Abstract

    AIMS

    To evaluate the impact of lipid-lowering treatment on cholesterol concentrations in the setting of normal care.

    METHODS

    This was a retrospective review of all cholesterol measurements made in Tayside, Scotland, between 1993 and 2002, linked to dispensed prescribing data for lipid-lowering drugs. It was conducted in the setting of normal care and included all patients who underwent cholesterol measurement. The main outcome measure was cholesterol concentration.

    RESULTS

    A total of 401 489 cholesterol measurements were made on 128 240 patients over the study period. Measurements were categorized as treated and untreated according to whether patients were exposed to lipid-lowering treatment at the time the total cholesterol concentration was measured. Those categorized as untreated fell by 0.86 mmol l(-1) (13.9%) and those categorized as treated by 1.45 mmol l(-1) (23.5%). The difference between baseline and follow-up cholesterol concentrations in intention-to-treat patients was 1.53 mmol l(-1) (24%) in 2002. In the same year, mean cholesterol concentration was 4.71 mmol l(-1) (a fall of 1.65 mmol l(-1) or 25.9%) in patients judged to be taking their lipid-lowering medication, compared with 5.20 mmol l(-1) (a fall of 1.16 mmol l(-1) or 18.2%) in those judged not to be taking treatment. Cholesterol fell by 0.38 mmol l(-1) (6.3%) in a cohort of never treated patients (n = 33 679) between 1993 and 2002.

    CONCLUSIONS

    The impact of lipid-lowering drugs on population cholesterol concentrations in the setting of normal care was significant and comparable with the cholesterol reductions seen in the setting of major statin trials, despite a significant proportion of the population receiving low dose treatment. In those subjects judged to be taking their medication, the benefits achieved were substantial. The impact of nondrug factors is indicated by the fall in population cholesterol seen in the absence of lipid-lowering treatment.

    Original languageEnglish
    Pages (from-to)587-592
    Number of pages6
    JournalBritish Journal of Clinical Pharmacology
    Volume65
    Issue number4
    DOIs
    Publication statusPublished - Apr 2008

    Keywords

    • Coronary heart disease
    • Effectiveness
    • Lipid-lowering treatment
    • Population cholesterol
    • Statin prescribing
    • Cardiovascular events
    • Pravastatin
    • Simvastatin
    • Prevention
    • Trial

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