Recent Advances in Development of Natural Cellulosic Non-Woven Scaffolds for Tissue Engineering

Mohammad Reza Aghazadeh, Sheyda Delfanian, Pouria Aghakhani, Shahin Homaeigohar, Atefeh Alipour (Lead / Corresponding author), Hosein Shahsavarani (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)
74 Downloads (Pure)


: In recent years, tissue engineering researchers have exploited a variety of biomaterials that can potentially mimic the extracellular matrix (ECM) for tissue regeneration. Natural cellulose, mainly obtained from bacterial (BC) and plant-based (PC) sources, can serve as a high-potential scaffold material for different regenerative purposes. Natural cellulose has drawn the attention of researchers due to its advantages over synthetic cellulose including its availability, cost effectiveness, perfusability, biocompatibility, negligible toxicity, mild immune response, and imitation of native tissues. In this article, we review recent in vivo and in vitro studies which aimed to assess the potential of natural cellulose for the purpose of soft (skin, heart, vein, nerve, etc.) and hard (bone and tooth) tissue engineering. Based on the current research progress report, it is sensible to conclude that this emerging field of study is yet to satisfy the clinical translation criteria, though reaching that level of application does not seem far-fetched.
Original languageEnglish
Article number1531
Number of pages19
Issue number8
Publication statusPublished - 9 Apr 2022


  • Bone regeneration
  • Cardiac regeneration
  • Natural cellulose
  • Neural regeneration
  • Skin regeneration
  • Tissue engineering
  • Vascular regeneration

ASJC Scopus subject areas

  • General Chemistry
  • Polymers and Plastics


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