Recent advances in the electrophysiological characterization of 5-HT3 receptors

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Abstract

5-HT3 receptors are ligand-gated, cation-selective ion channels, mediating membrane depolarization and neuronal excitation. Established and potential therapeutic applications of selective 5-HT3 receptor antagonists, coupled with the localization of this receptor subtype within discrete areas of the CNS, have resulted in an intensification of research in this area. In this review, Jeremy Lambert and colleagues summarize recent developments in the electro-physiological characterization of 5-HT3 receptors, and comment upon the unresolved issue of 5-HT3 receptor heterogeneity.

Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalTrends in Pharmacological Sciences
Volume13
DOIs
Publication statusPublished - 1992

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