Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance

P. J. Connelly (Lead / Corresponding author), N. Smith, R. Chadwick, A. R. Exley, J. M. Shneerson, E. R. Pearson (Lead / Corresponding author)

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    Abstract

    AIM: To investigate glucose and insulin metabolism in participants with ataxia telangiectasia in the absence of a diagnosis of diabetes.

    METHODS: A standard oral glucose tolerance test was performed in participants with ataxia telangiectasia (n=10) and in a control cohort (n=10). Serial glucose and insulin measurements were taken to permit cohort comparisons of glucose-insulin homeostasis and indices of insulin secretion and sensitivity.

    RESULTS: During the oral glucose tolerance test, the 2-h glucose (6.75 vs 4.93 mmol/l; P=0.029), insulin concentrations (285.6 vs 148.5 pmol/l; P=0.043), incremental area under the curve for glucose (314 vs 161 mmol/l/min; P=0.036) and incremental area under the curve for insulin (37,720 vs 18,080 pmol/l/min; P =0.03) were higher in participants with ataxia telangiectasia than in the controls. There were no significant differences between groups in fasting glucose, insulin concentrations or insulinogenic index measurement (0.94 vs 0.95; P=0.95). The Matsuda index, reflecting whole-body insulin sensitivity, was lower in participants with ataxia telangiectasia (5.96 vs 11.03; P=0.019) than in control subjects.

    CONCLUSIONS: Mutations in Ataxia Telangiectasia Mutated (ATM) that cause ataxia telangiectasia are associated with elevated glycaemia and low insulin sensitivity in participants without diabetes. This indicates a role of ATM in glucose and insulin metabolic pathways. This article is protected by copyright. All rights reserved.

    Original languageEnglish
    Pages (from-to)371-375
    Number of pages5
    JournalDiabetic Medicine
    Volume33
    Issue number3
    Early online date24 Dec 2015
    DOIs
    Publication statusPublished - Mar 2016

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