Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

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    Abstract

    In order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis and early G1 by assembling complexes of Mcm2-7 onto them. Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle.
    Original languageEnglish
    JournalBMC Biochemistry
    Volume2
    Issue number15
    DOIs
    Publication statusPublished - 2001

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