Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

TY - JOUR

T1 - Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins

AU - Gillespie, Peter J

AU - Li, Anatoliy

AU - Blow, J. Julian

PY - 2001

Y1 - 2001

N2 - In order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis and early G1 by assembling complexes of Mcm2-7 onto them. Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle.

AB - In order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis and early G1 by assembling complexes of Mcm2-7 onto them. Mcm2-7 are essential for DNA replication, but are displaced from origins as they initiate, thus ensuring that no origin fires more than once in a single cell cycle.

U2 - 10.1186/1471-2091-2-15

DO - 10.1186/1471-2091-2-15

M3 - Article

C2 - 11737877

SN - 1472-2091

VL - 2

JO - BMC Biochemistry

JF - BMC Biochemistry

IS - 15

ER -