Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin

D. de Berker, S. Ibbotson, N. B. Simpson, J. L. Rees, J. N. S. Matthews, J. R. Idle

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    13 Citations (Scopus)

    Abstract

    Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) show clinical and epidemiological differences not accounted for by different ultraviolet radiation exposure. We have studied experimentally induced contact sensitivity to dinitrochlorobenzene by measuring increases in skin-fold thickness. Patients (n = 37) with squamous tumours had impaired responses compared with controls (33) and patients with BCCs (31) (mean increase 4.5 vs 7.8 and 8.6 mm, respectively; p = 0.002). This diminished immunological response may be causally related to the development of SCC. Because glutathione S-transferase (GST) metabolises dinitrochlorobenzene and polymorphisms of GST are associated with multiple skin tumours, variations in GST may underlie these differences.
    Original languageEnglish
    Pages (from-to)425-426
    Number of pages2
    JournalLancet
    Volume345
    Issue number8947
    DOIs
    Publication statusPublished - 18 Feb 1995

    Keywords

    • Dinitrochlorobenzene
    • Prospective Studies
    • Humans
    • Dose-Response Relationship, Immunologic
    • Glutathione Transferase
    • Case-Control Studies
    • Carcinoma, Basal Cell
    • Skin Neoplasms
    • Carcinoma, Squamous Cell
    • Dermatitis, Contact
    • Male
    • Female

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    de Berker, D., Ibbotson, S., Simpson, N. B., Rees, J. L., Matthews, J. N. S., & Idle, J. R. (1995). Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin. Lancet, 345(8947), 425-426. https://doi.org/10.1016/S0140-6736(95)90406-9