Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin

D. de Berker; S. Ibbotson; N. B. Simpson; J. L. Rees; J. N. S. Matthews; J. R. Idle

doi:10.1016/S0140-6736(95)90406-9

Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin

D. de Berker, S. Ibbotson, N. B. Simpson, J. L. Rees, J. N. S. Matthews, J. R. Idle

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) show clinical and epidemiological differences not accounted for by different ultraviolet radiation exposure. We have studied experimentally induced contact sensitivity to dinitrochlorobenzene by measuring increases in skin-fold thickness. Patients (n = 37) with squamous tumours had impaired responses compared with controls (33) and patients with BCCs (31) (mean increase 4.5 vs 7.8 and 8.6 mm, respectively; p = 0.002). This diminished immunological response may be causally related to the development of SCC. Because glutathione S-transferase (GST) metabolises dinitrochlorobenzene and polymorphisms of GST are associated with multiple skin tumours, variations in GST may underlie these differences.

Original language	English
Pages (from-to)	425-426
Number of pages	2
Journal	Lancet
Volume	345
Issue number	8947
DOIs	https://doi.org/10.1016/S0140-6736(95)90406-9
Publication status	Published - 18 Feb 1995

Keywords

Dinitrochlorobenzene
Prospective Studies
Humans
Dose-Response Relationship, Immunologic
Glutathione Transferase
Case-Control Studies
Carcinoma, Basal Cell
Skin Neoplasms
Carcinoma, Squamous Cell
Dermatitis, Contact
Male
Female

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10.1016/S0140-6736(95)90406-9

Cite this

@article{327ac110a75b48bf9bf0ec8d3d0bfd1f,

title = "Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin",

abstract = "Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) show clinical and epidemiological differences not accounted for by different ultraviolet radiation exposure. We have studied experimentally induced contact sensitivity to dinitrochlorobenzene by measuring increases in skin-fold thickness. Patients (n = 37) with squamous tumours had impaired responses compared with controls (33) and patients with BCCs (31) (mean increase 4.5 vs 7.8 and 8.6 mm, respectively; p = 0.002). This diminished immunological response may be causally related to the development of SCC. Because glutathione S-transferase (GST) metabolises dinitrochlorobenzene and polymorphisms of GST are associated with multiple skin tumours, variations in GST may underlie these differences.",

keywords = "Dinitrochlorobenzene, Prospective Studies, Humans, Dose-Response Relationship, Immunologic, Glutathione Transferase, Case-Control Studies, Carcinoma, Basal Cell, Skin Neoplasms, Carcinoma, Squamous Cell, Dermatitis, Contact, Male, Female",

author = "{de Berker}, D. and S. Ibbotson and Simpson, {N. B.} and Rees, {J. L.} and Matthews, {J. N. S.} and Idle, {J. R.}",

year = "1995",

month = feb,

day = "18",

doi = "10.1016/S0140-6736(95)90406-9",

language = "English",

volume = "345",

pages = "425--426",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier",

number = "8947",

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TY - JOUR

T1 - Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin

AU - de Berker, D.

AU - Ibbotson, S.

AU - Simpson, N. B.

AU - Rees, J. L.

AU - Matthews, J. N. S.

AU - Idle, J. R.

PY - 1995/2/18

Y1 - 1995/2/18

N2 - Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) show clinical and epidemiological differences not accounted for by different ultraviolet radiation exposure. We have studied experimentally induced contact sensitivity to dinitrochlorobenzene by measuring increases in skin-fold thickness. Patients (n = 37) with squamous tumours had impaired responses compared with controls (33) and patients with BCCs (31) (mean increase 4.5 vs 7.8 and 8.6 mm, respectively; p = 0.002). This diminished immunological response may be causally related to the development of SCC. Because glutathione S-transferase (GST) metabolises dinitrochlorobenzene and polymorphisms of GST are associated with multiple skin tumours, variations in GST may underlie these differences.

AB - Basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) show clinical and epidemiological differences not accounted for by different ultraviolet radiation exposure. We have studied experimentally induced contact sensitivity to dinitrochlorobenzene by measuring increases in skin-fold thickness. Patients (n = 37) with squamous tumours had impaired responses compared with controls (33) and patients with BCCs (31) (mean increase 4.5 vs 7.8 and 8.6 mm, respectively; p = 0.002). This diminished immunological response may be causally related to the development of SCC. Because glutathione S-transferase (GST) metabolises dinitrochlorobenzene and polymorphisms of GST are associated with multiple skin tumours, variations in GST may underlie these differences.

KW - Dinitrochlorobenzene

KW - Prospective Studies

KW - Humans

KW - Dose-Response Relationship, Immunologic

KW - Glutathione Transferase

KW - Case-Control Studies

KW - Carcinoma, Basal Cell

KW - Skin Neoplasms

KW - Carcinoma, Squamous Cell

KW - Dermatitis, Contact

KW - Male

KW - Female

U2 - 10.1016/S0140-6736(95)90406-9

DO - 10.1016/S0140-6736(95)90406-9

M3 - Article

C2 - 7853955

SN - 0140-6736

VL - 345

SP - 425

EP - 426

JO - Lancet

JF - Lancet

IS - 8947

ER -

Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin

Abstract

Keywords

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