Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

K. G. J. Pollock, K. Kavanagh, A. Potts, J. Love, K. Cuschieri, H. Cubie, C. Robertson, M. Cruickshank, T. J. Palmer, S. Nicoll, M. Donaghy

    Research output: Contribution to journalArticle

    104 Citations (Scopus)
    137 Downloads (Pure)

    Abstract

    Background:

    In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established.

    Methods:

    We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20–21 in 2008–2012.

    Results:

    By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women.

    Conclusions:

    To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake.
    Original languageEnglish
    Pages (from-to)1824-1830
    Number of pages7
    JournalBritish Journal of Cancer
    Volume111
    Issue number9
    DOIs
    Publication statusPublished - 28 Oct 2014

    Fingerprint Dive into the research topics of 'Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland'. Together they form a unique fingerprint.

  • Cite this

    Pollock, K. G. J., Kavanagh, K., Potts, A., Love, J., Cuschieri, K., Cubie, H., Robertson, C., Cruickshank, M., Palmer, T. J., Nicoll, S., & Donaghy, M. (2014). Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland. British Journal of Cancer, 111(9), 1824-1830. https://doi.org/10.1038/bjc.2014.479