TY - JOUR
T1 - Reductionist Pathways for Parasitism in Euglenozoans? Expanded Datasets Provide New Insights
AU - Butenko, Anzhelika
AU - Hammond, Michael
AU - Field, Mark C.
AU - Ginger, Michael L.
AU - Yurchenko, Vyacheslav
AU - Lukeš, Julius
N1 - Funding Information:
We are grateful to Ambar Kachale (Institute of Parasitology) for help with the figures, Gertraud Burger (University of Montreal) for sharing D. papillatum histone sequences, and Fred Opperdoes (de Duve Institute) for helpful discussions. This work was supported by the Czech Grant Agency 18-15962S and 20-07186S , ERC CZ LL1601 , and the ERD Funds project OPVVV 0000759 . M.C.F. is a Welcome Trust Investigator.
Funding Information:
We are grateful to Ambar Kachale (Institute of Parasitology) for help with the figures, Gertraud Burger (University of Montreal) for sharing D. papillatum histone sequences, and Fred Opperdoes (de Duve Institute) for helpful discussions. This work was supported by the Czech Grant Agency 18-15962S and 20-07186S, ERC CZ LL1601, and the ERD Funds project OPVVV 0000759. M.C.F. is a Welcome Trust Investigator.
Publisher Copyright:
© 2020 Elsevier Ltd
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - The unicellular trypanosomatids belong to the phylum Euglenozoa and all known species are obligate parasites. Distinct lineages infect plants, invertebrates, and vertebrates, including humans. Genome data for marine diplonemids, together with freshwater euglenids and free-living kinetoplastids, the closest known nonparasitic relatives to trypanosomatids, recently became available. Robust phylogenetic reconstructions across Euglenozoa are now possible and place the results of parasite-focused studies into an evolutionary context. Here we discuss recent advances in identifying the factors shaping the evolution of Euglenozoa, focusing on ancestral features generally considered parasite-specific. Remarkably, most of these predate the transition(s) to parasitism, suggesting that the presence of certain preconditions makes a significant lifestyle change more likely.
AB - The unicellular trypanosomatids belong to the phylum Euglenozoa and all known species are obligate parasites. Distinct lineages infect plants, invertebrates, and vertebrates, including humans. Genome data for marine diplonemids, together with freshwater euglenids and free-living kinetoplastids, the closest known nonparasitic relatives to trypanosomatids, recently became available. Robust phylogenetic reconstructions across Euglenozoa are now possible and place the results of parasite-focused studies into an evolutionary context. Here we discuss recent advances in identifying the factors shaping the evolution of Euglenozoa, focusing on ancestral features generally considered parasite-specific. Remarkably, most of these predate the transition(s) to parasitism, suggesting that the presence of certain preconditions makes a significant lifestyle change more likely.
KW - diplonemids
KW - Euglenozoa
KW - evolution
KW - kinetoplastids
KW - metabolism
KW - parasitism
UR - http://www.scopus.com/inward/record.url?scp=85094585309&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2020.10.001
DO - 10.1016/j.pt.2020.10.001
M3 - Review article
C2 - 33127331
AN - SCOPUS:85094585309
SN - 1471-4922
VL - 37
SP - 100
EP - 116
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 2
ER -
