Regulation and function of CMTR1-dependent mRNA cap methylation

Francisco Inesta-Vaquera, Victoria H. Cowling (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    21 Citations (Scopus)
    274 Downloads (Pure)


    mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or "self" in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.
    Original languageEnglish
    Article numbere1450
    Pages (from-to)1-6
    Number of pages6
    JournalWiley Interdisciplinary Reviews: RNA
    Issue number6
    Early online date2 Oct 2017
    Publication statusPublished - Nov 2017


    Dive into the research topics of 'Regulation and function of CMTR1-dependent mRNA cap methylation'. Together they form a unique fingerprint.

    Cite this