TY - JOUR
T1 - Regulation and function of CMTR1-dependent mRNA cap methylation
AU - Inesta-Vaquera, Francisco
AU - Cowling, Victoria H.
N1 - VHC and FIV are funded by an MRC Senior Fellowship MR/K024213/1, Lister Institute Prize Fellowship and a Wellcome Trust Centre award 097945/Z/11/Z.
PY - 2017/11
Y1 - 2017/11
N2 - mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or "self" in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.
AB - mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or "self" in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.
U2 - 10.1002/wrna.1450
DO - 10.1002/wrna.1450
M3 - Review article
C2 - 28971629
SN - 1757-7004
VL - 8
SP - 1
EP - 6
JO - Wiley Interdisciplinary Reviews: RNA
JF - Wiley Interdisciplinary Reviews: RNA
IS - 6
M1 - e1450
ER -