Regulation and function of CMTR1-dependent mRNA cap methylation

Francisco Inesta-Vaquera, Victoria H. Cowling (Lead / Corresponding author)

Research output: Contribution to journalReview article

8 Citations (Scopus)
132 Downloads (Pure)

Abstract

mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or "self" in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.
Original languageEnglish
Article numbere1450
Pages (from-to)1-6
Number of pages6
JournalWiley Interdisciplinary Reviews: RNA
Volume8
Issue number6
Early online date2 Oct 2017
DOIs
Publication statusPublished - Nov 2017

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Methylation
Ribose
Innate Immunity
Messenger RNA
Nucleotides
Molecular interactions
Guanosine
Methyltransferases
Gene expression
Gene Expression
Proteins

Cite this

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title = "Regulation and function of CMTR1-dependent mRNA cap methylation",
abstract = "mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or {"}self{"} in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.",
author = "Francisco Inesta-Vaquera and Cowling, {Victoria H.}",
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AU - Inesta-Vaquera, Francisco

AU - Cowling, Victoria H.

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N2 - mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or "self" in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.

AB - mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or "self" in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function.

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DO - 10.1002/wrna.1450

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