Regulation of cell migration during chick gastrulation

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    Abstract

    Gastrulation in chick starts with large-scale cell flows in the epiblast and hypoblast, which transport the mesendoderm into the midline of the embryo to form the primitive streak. Several mechanisms such as cell-cell intercalation, deformations of the extracellular matrix and directed cell movements in response to chemical gradients have been proposed to play a role in streak formation. In the streak the epiblast cells undergo an epithelial to mesenchymal transition (EMT), which involves the breakdown of apical junctions and changes in RhoA-dependent signalling to integrins that mediated contact with the basal lamina. The collective migration of the mesendoderm away from the streak appears to be controlled by gradients of growth factors of the FGF and VEGF and Writ families and requires N-cadherin expression. The timing and order of ingression of epiblast cells appears to be controlled by temporal and spatial colinearity of Hox gene expression in the epiblast. The mechanisms by which Hox genes control these properties remain to be resolved.

    Original languageEnglish
    Pages (from-to)343-349
    Number of pages7
    JournalCurrent Opinion in Genetics & Development
    Volume19
    Issue number4
    DOIs
    Publication statusPublished - Aug 2009

    Keywords

    • Primitive streak form
    • Movement patterns
    • Mesoderm cells
    • Embryo
    • Expression
    • Genes
    • WNT
    • Ingression
    • Transition
    • Induction

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